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Article
Open AccessAn Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies
The pH-selective interaction between the immunoglobulin G (IgG) fragment crystallizable region (Fc region) and the neonatal Fc receptor (FcRn) is critical for prolonging the circulating half-lives of IgG molec...
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Article
Open AccessThe acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells
Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the cancer, and tumor acidosis has been sh...
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Article
Open AccessDeubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA
IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays...
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Article
Manufacturing and Control of a Robotic Device for Time-averaged Simulated Micro and Partial Gravity of a Cell Culture Environment
Gravity is omnipresent for all objects on Earth. However, in an environment of different gravitational stress (e.g., microgravity or partial gravity), cells and organs show different biological responses. So, ...
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Article
Open AccessExtracellular Microenvironmental Change by B16F10 Melanoma-derived Proteins Induces Cancer Stem-like Cell Properties from NIH3T3 Cells
Cancer stem-like cells (CSCs) can generate solid tumors through the properties of stem cells such as self-renewal and differentiation and they cause drug resistance, metastasis and recurrence. Therefore, estab...
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Article
Open AccessMicrogravity induces autophagy via mitochondrial dysfunction in human Hodgkin’s lymphoma cells
Gravitational forces can impose physical stresses on the human body as it functions to maintain homeostasis. It has been reported that astronauts exposed to microgravity experience altered biological functions...
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Article
Open AccessTime-averaged simulated microgravity (taSMG) inhibits proliferation of lymphoma cells, L-540 and HDLM-2, using a 3D clinostat
Gravity is omnipresent on Earth; however, humans in space, such as astronauts at the International Space Station, experience microgravity. Long-term exposure to microgravity is considered to elicit physiologic...
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Article
IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells
Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberra...
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Article
Open AccessPatient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway
Mutation of PPP2R1A has been observed at high frequency in endometrial serous carcinomas but at low frequency in ovarian clear cell carcinoma. However, the biological role of mutation of PPP2R1A in ovarian and en...
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Article
Interleukin-32β stimulates migration of MDA-MB-231 and MCF-7cells via the VEGF-STAT3 signaling pathway
IL-32 is known to play an important role in inflammatory and autoimmune disease responses. In addition to its role in these responses, IL-32 and its different isoforms have in recent years been implicated in t...
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Article
Herb mixture C5E aggravates doxorubicin-induced apoptosis of human breast cancer cell lines
A number of extracts from Asian traditional medicinal herbs have been successfully used as therapeutic agents against cancers. In this study we assessed the effect of C5E on the proliferation inhibition and ap...
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Article
Subcutaneous panniculitis-like T-cell lymphoma: US and CT findings in three patients
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare disorder. We examined two females and one male with multiple soft-tissue masses in the abdominal wall. One of these three patients also had soft...
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Article
Characterization of Hydrophobic SiO2 Powders Prepared by Surface Modification on Wet Gel
Hydrophobic porous silica has been prepared by surface modification of TEOS (tetraethylorthosilicate) wet gel with 6 and 12 vol.% of TMCS (trimethylchlorosilane). We characterized the products by using FT-IR, ...
