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  1. Article

    rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits

    BriLife®, a vector-based vaccine that utilizes the recombinant vesicular stomatitis virus (VSV) platform to express and present the spike antigen of SARS-CoV-2, is undergoing testing in a phase 2 clinical trial i...

    Amir Rosner, Michal Steiner, Sharon Melamed, Boaz Politi… in Archives of Toxicology (2022)

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  2. Article

    Spike vs nucleocapsid SARS-CoV-2 antigen detection: application in nasopharyngeal swab specimens

    Public health experts emphasize the need for quick, point-of-care SARS-CoV-2 detection as an effective strategy for controlling virus spread. To this end, many “antigen” detection devices were developed and co...

    Moria Barlev-Gross, Shay Weiss, Amir Ben-Shmuel… in Analytical and Bioanalytical Chemistry (2021)

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  3. Article

    Open Access

    Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

    The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits high levels of mortality and morbidity and has dramatic consequences on hu...

    Ronit Rosenfeld, Tal Noy-Porat, Adva Mechaly, Efi Makdasi… in Nature Communications (2021)

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  4. Article

    Open Access

    A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

    The novel highly transmissible human coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Thus far, there is no approved therapeutic drug specifically targeting this emerging virus. Here we ...

    Tal Noy-Porat, Efi Makdasi, Ron Alcalay, Adva Mechaly, Yinon Levy… in Nature Communications (2020)

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  5. Article

    Open Access

    Inhibition of Francisella tularensis phagocytosis using a novel anti-LPS scFv antibody fragment

    Francisella tularensis (Ft), the causative agent of lethal tularemia, is classified as a category A biological warfare threat agent. While Ft infection is treatable by antibiotics, many failed antibiotic treatmen...

    Adva Mechaly, Uri Elia, Ron Alcalay, Hila Cohen, Eyal Epstein… in Scientific Reports (2019)

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  6. No Access

    Article

    Rapid Homogenous Time-Resolved Fluorescence (HTRF) Immunoassay for Anthrax Detection

    Infection with Bacillus anthracsis spores induces an acute anthrax disease that can cause casualties and death in untreated cases. Thus rapid diagnosis of anthrax at early stage of the disease is essential to all...

    Noam Cohen, Adva Mechaly, Ohad Mazor, Morly Fisher, Eran Zahavy in Journal of Fluorescence (2014)

  7. No Access

    Article

    A novel homogeneous immunoassay for anthrax detection based on the AlphaLISA method: detection of B. anthracis spores and protective antigen (PA) in complex samples

    Amplified Luminescent Proximity Homogeneous Assay (AlphaLISA) technology is an energy-transfer-based assay, utilizing singlet oxygen as an energy donor to a fluorescent acceptor. The long singlet oxygen migrat...

    Adva Mechaly, Noam Cohen, Shay Weiss, Eran Zahavy in Analytical and Bioanalytical Chemistry (2013)

  8. No Access

    Chapter and Conference Paper

    Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect

    In order to mimic the neutralizing potency of polyclonal antibodies, combinations of neutralizing monoclonal antibodies (mAbs) are used. The main pre-requisite of any preparation which is comprised of several ...

    Ohad Mazor, Einat Ben-Arie, Adva Mechaly… in The Challenge of Highly Pathogenic Microor… (2010)