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  1. Article

    Open Access

    Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS

    Polycystic ovarian syndrome (PCOS) is a known endocrine disorder that has affected many women of childbearing age, and is accompanied by various neurodegenerative conditions. Hence, this study investigates the...

    Oony-Iye Eepho, Al-Amin M. Bashir, Adesola A. Oniyide, Ayodeji Aturamu… in BMC Neuroscience (2023)

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    Article

    Mineralocorticoid receptor blockade attenuates hyperandrogenic metabolic dysregulation in letrozole-induced PCOS rat model

    Polycystic ovarian syndrome (PCOS) is a metabolic syndrome associated with mineralocorticoid receptor (MR) activation, which causes infertility in women of reproductive age. Spironolactone (SPL) is a MR blocke...

    Efosa G. Uhunmwangho, Adesola A. Oniyide… in Journal of Diabetes & Metabolic Disorders (2022)

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    Article

    Acetate supplementation restores testicular function by modulating Nrf2/PPAR-γ in high fat diet-induced obesity in Wistar rats

    Several studies have established impaired testicular function in obese male population, including the young males with childhood obesity, contributing to increased male infertility, which is a universal trend ...

    Kehinde S. Olaniyi, Christopher O. Akintayo… in Journal of Diabetes & Metabolic Disorders (2021)