29 Result(s)
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Adebowale A. Adeyemo
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Open AccessUntargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology of T2D remain scarce outside Europe and North America. The aim...
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Open AccessPerceptions and beliefs of community gatekeepers about genomic risk information in African cleft research
A fundamental ethical issue in African genomics research is how socio-cultural factors impact perspectives, acceptance, and utility of genomic information, especially in stigmatizing conditions like orofacial ...
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Open AccessMendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes
In vitro and in vivo studies have shown that certain cytokines and hormones may play a role in the development and progression of type 2 diabetes (T2D). However, studies on their role in T2D in humans are scar...
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Open AccessUnappreciated subcontinental admixture in Europeans and European Americans and implications for genetic epidemiology studies
European-ancestry populations are recognized as stratified but not as admixed, implying that residual confounding by locus-specific ancestry can affect studies of association, polygenic adaptation, and polygen...
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Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Open AccessMendelian randomization study reveals a causal relationship between adiponectin and LDL cholesterol in Africans
Adiponectin has been associated with cardiometabolic traits in observational studies across populations, yet it is unclear if these associations are causal. We performed Mendelian randomization (MR) analysis t...
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Open AccessAn epigenome-wide association study of insulin resistance in African Americans
African Americans have a high risk for type 2 diabetes (T2D) and insulin resistance. Studies among other population groups have identified DNA methylation loci associated with insulin resistance, but data in A...
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Open AccessWhole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate
The majority (85%) of nonsyndromic cleft lip with or without cleft palate (nsCL/P) cases occur sporadically, suggesting a role for de novo mutations (DNMs) in the etiology of nsCL/P. To identify high impact pr...
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Open AccessMeta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledg...
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Open AccessEpigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus
Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures ...
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Evolutionary genetics and acclimatization in nephrology
Evolutionary processes, including mutation, migration and natural selection, have influenced the prevalence and distribution of various disorders in humans. However, despite a few well-known examples, such as ...
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Open AccessGenome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits
A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of th...
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Plasma cell immunoglobulin heavy chain repertoire dynamics before and after tetanus booster vaccination
Antibody sequence repertoire analysis of plasma cells (PC) isolated before and 1 week after a vaccine provides time-specific snapshots of the antibody response. Comparison of the immunoglobulin (Ig) sequences ...
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Open AccessAuthor Correction: High-depth African genomes inform human migration and health
A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03286-9.
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Open AccessEndemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility
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Author Correction to: Endemic Burkitt lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility
A Correction to this paper has been published: https://doi.org/10.1038/s41375-021-01140-5
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Open AccessGenome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection
Genetic factors may influence the susceptibility to high-risk (hr) human papillomavirus (HPV) infection and persistence. We conducted the first genome-wide association study (GWAS) to identify variants associa...
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High-depth African genomes inform human migration and health
The African continent is regarded as the cradle of modern humans and African genomes contain more genetic variation than those from any other continent, yet only a fraction of the genetic diversity among Afric...
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Open AccessAssociations of autozygosity with a broad range of human phenotypes
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because...
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Open AccessZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type ...
