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  1. No Access

    Article

    Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

    In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through accurate assessment of minimal residual disease (MRD) and therapeutic response monitoring. To overcome the sparsity of...

    Adam J. Widman, Minita Shah, Amanda Frydendahl, Daniel Halmos… in Nature Medicine (2024)

  2. Article

    CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer

    Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hosp...

    Erin M. Bange, Nicholas A. Han, Paul Wileyto, Justin Y. Kim… in Nature Medicine (2021)

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    Article

    Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

    In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (...

    Asaf Zviran, Rafael C. Schulman, Minita Shah, Steven T. K. Hill… in Nature Medicine (2020)