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Article
Angiotensin Converting Enzyme Inhibitors Ameliorate Brain Inflammation Associated with Microglial Activation: Possible Implications for Alzheimer’s Disease
Angiotensin converting enzyme (ACE) converts Angiotensin I to a potent vasoconstrictor angiotensin II (ANG II). ACE inhibitors (ACEIs) are widely used for the management of hypertension. All components of the ...
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Article
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells
Transduction of tumor cells with herpes simplex virus thymidine kinase (HSV-tk) gene and subsequent treatment with the prodrug ganciclovir (GCV) is the most common system utilized to date for “suicide” gene th...
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Article
Multiple-Dose Studies can be a More Sensitive Assessment for Bioequivalence than Single-Dose Studies
To evaluate the bioequivalence of two enteric-coated formulations of omeprazole, Losec® (reference) and Omepradex® (test). It is hypothesised that formulation differences may be accentuated following multiple-...
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Chapter
Differential Effect of Corticotropin Releasing Factor on Interleukin-1α and Interleukin-1β-Induced Prostaglandin Synthesis in Endothelial Cells and Fibroblasts
The inflammatory response involves two major pathways: one comprises the immune response, predominantly mediated by cytokines such as interleukin 1 (IL-1). The other pathway involves neuroendocrine mechanisms,...
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Article
Pharmacokinetics of recombinant interferon alpha-C
Recombinant interferon alpha-C (rIFNα-C, Interpharm), is a new type of alpha-interferon that has a specific activity of 1–2×109 units/mg protein. The pharmacokinetics of rIFNα-C were studied in 11 patients with m...
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Chapter
Serum Amyloid A, an Acute Phase Protein, Inhibits Platelet Activation
Serum amyloid A is an acute phase protein known to circulate in blood as a component of high density lipoprotein. Platelets and mediators released from activated platelets are involved in various inflammatory ...
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Chapter
Acute Phase Protein, Serum Amyloid A, Inhibits IL-1- and Tnf-Induced Fever and Hypothalamic Pge2 in Mice
The effect of serum amyloid A (SAA) on fever, induced by recombinant interleukin-1ß (rIL-1ß) or recombinant tumor necrosis factor a (rTNFα), was studied in mice. Serum amyloid A is an acute phase protein whose...
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Article
Acetaminophen hepatotoxicity: Is there a role for prostaglandin synthesis?
The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be coox...
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Article
Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex
Lithium is a unique drug with therapeutic as well as prophylactic value for both manic and depressive phases of manic-depressive illness,1,2. The precise mechanisms of its clinical efficacy remain unknown, but th...
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Article
Inhibition of prostaglandin biosynthesis by corticosteroids requires RNA and protein synthesis
THE finding that aspirin-like drugs act by inhibiting prostaglandin (PG) synthetase was reported by Vane et al.1, and the possible effects of anti-inflammatory steroids on PG production have since been a matter o...
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Article
ESSENTIAL FATTY ACIDS (EFA) IN CORD BLOOD OF THIRD TRIMESTER INFANTS AND MATERNAL PLASMA
EFA are incorporated into brain lipids and serve as prostaglandin (PG) precursors. Increased CNS morbidity in low birthweight infants is well recognized. Plasma levels and EFA were measured in phospholipids (P...
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Article
Effects of sex on formation and properties of plasma very low density lipoprotein in vivo
The concentration and composition of the very low density lipoprotein (VLDL) lipids and the behavior of the VLDL in a density gradient in the zonal ultracentrifuge were examined in plasma obtained from normal ...
