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  1. No Access

    Article

    Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of age-related neurodegenerative diseases: an emerging therapeutic approach

    Aging-induced neurodegenerative diseases (NDs) are significantly increasing health problem worldwide. It has been well documented that oxidative stress is one of the potential causes of aging and age-related N...

    Apoorv Sharma, Abhishek Kumar Singh in Biogerontology (2023)

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    Article

    Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and d-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging

    Spermidine (SPD) is a natural polyamine present in all living organisms and is involved in the maintenance of cellular homeostasis by inducing autophagy in different model organisms. Its role as a caloric rest...

    Sandeep Singh, Raushan Kumar, Geetika Garg, Abhishek Kumar Singh… in Biogerontology (2021)

  3. No Access

    Article

    Whey protein concentrate protects against age-dependent alteration in redox biomarkers

    Aging is associated with decreased cellular cysteine uptake, which acts as a precursor for glutathione biosynthesis. Whey protein, a liquid aspect of milk, is an effective cysteine delivery system. The study w...

    Geetika Garg, Abhishek Kumar Singh, Sandeep Singh, Avnish Kumar Verma… in Biologia Futura (2020)

  4. No Access

    Article

    Proteomics in Human Parkinson’s Disease: Present Scenario and Future Directions

    Parkinson’s disease (PD) is an age-related, threatening neurodegenerative disorder with no reliable treatment till date. Identification of specific and reliable biomarker is a major challenge for disease diagn...

    Anubhuti Dixit, Rachna Mehta, Abhishek Kumar Singh in Cellular and Molecular Neurobiology (2019)

  5. No Access

    Article

    Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

    Autophagy is an evolutionary conserved catabolic process that ensures continuous removal of damaged cell organelles and long-lived protein aggregates to maintain cellular homeostasis. Although autophagy has be...

    Abhishek Kumar Singh, Akalabya Bissoyi, Mahendra Pratap Kashyap… in Neurotoxicity Research (2017)

  6. No Access

    Article

    Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

    Autophagy is a catabolic process involved in the continuous removal of toxic protein aggregates and cellular organelles to maintain the homeostasis and functional integrity of cells. The mechanistic understand...

    Abhishek Kumar Singh, Mahendra Pratap Kashyap… in Molecular Neurobiology (2017)

  7. No Access

    Article

    The M. tuberculosis HAD phosphatase (Rv3042c) interacts with host proteins and is inhibited by Clofazimine

    Mycobacterium tuberculosis codes for a HAD-phosphatase, Rv3042c (MtSerB2), that has earlier been characterized as a metabolic enzyme. Here we demonstrate that MtSerB2 is secreted into the...

    Sonal Shree, Abhishek Kumar Singh, Richa Saxena… in Cellular and Molecular Life Sciences (2016)

  8. No Access

    Article

    An Overview on Human Umbilical Cord Blood Stem Cell-Based Alternative In Vitro Models for Developmental Neurotoxicity Assessment

    The develo** brain is found highly vulnerable towards the exposure of different environmental chemicals/drugs, even at concentrations, those are generally considered safe in mature brain. The brain developme...

    Abhishek Kumar Singh, Mahendra Pratap Kashyap in Molecular Neurobiology (2016)