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  1. No Access

    Chapter and Conference Paper

    Evolution of neuropeptide concepts illustrated by MIF-1 and MSH

    Melanocyte-stimulating hormone (MSH) release-inhibiting factor (MIF)-1 is a tripeptide mainly produced by the hypothalamus. Since its discovery in 1968, MIF-1 has invoked a rich body of literature elucidating ...

    Weihong Pan, Abba J. Kastin in Transmitters and Modulators in Health and Disease (2009)

  2. Article

    Increased Leptin Permeation across the Blood–Brain Barrier after Chronic Alcohol Ingestion

    Leptin, a polypeptide mainly produced in the periphery, crosses the blood–brain barrier (BBB) by receptor-mediated transport to exert multiple central nervous system actions including decreased food intake. Th...

    Weihong Pan, Misty Barron, Hung Hsuchou, Hong Tu, Abba J Kastin in Neuropsychopharmacology (2008)

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    Chapter

    Peptide Transport System-1

    Saturable transport across the blood-brain barrier (BBB) has been described for several peptides (Table 1) and regulatory proteins from numerous laboratories1–5. The existence of transporters at the BBB for regul...

    William A. Banks, Abba J. Kastin in New Concepts of a Blood—Brain Barrier (1995)

  4. No Access

    Chapter

    Neuropeptide Modulation of Development and Behavior

    Peptides are very simple molecules composed of amino acids linked by bonds resulting from the elimination of water between an amino group in one molecule and a carboxyl group in an adjacent molecule. Neuropept...

    Curt A. Sandman, Abba J. Kastin in Application of Basic Neuroscience to Child Psychiatry (1990)

  5. No Access

    Chapter

    Exchange of Peptides Between the Circulation and the Nervous System: Role of the Blood-Brain Barrier

    Peptides can cross the blood-brain barrier (BBB) bidirectionally, that is, from the central nervous system (CNS) to the blood or from the blood to the CNS. Passage occurs by both saturable and nonsaturable mec...

    William A. Banks, Abba J. Kastin in Circulating Regulatory Factors and Neuroen… (1990)

  6. No Access

    Chapter

    Relationship of Clinical to Basic Research with Peptides as lllustrated by MSH

    Many of the principles that are now influencing the field of brain peptides were established more than a decade ago with melanocyte-stimulating hormone (MSH). A series of studies with MSH demonstrated not only...

    Abba J. Kastin, Richard D. Olson… in Neural and Endocrine Peptides and Receptors (1986)

  7. Article

    Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

    Extract: Luteinizing hormone-releasing hormone (LH-RH), purified from porcine hypothalamic tissue, was administered in an intravenous dose of 300 $mUg to four prepubertal and four adult human subjects. The result...

    Abba J Kastin, Andrew V Schally, Don S Schalch, Stanley G Korenman… in Pediatric Research (1972)

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