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Evolution of neuropeptide concepts illustrated by MIF-1 and MSH

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Transmitters and Modulators in Health and Disease

Summary

Melanocyte-stimulating hormone (MSH) release-inhibiting factor (MIF)-1 is a tripeptide mainly produced by the hypothalamus. Since its discovery in 1968, MIF-1 has invoked a rich body of literature elucidating its biochemical properties, cellular actions, effects on animal behavior, and therapeutic potential in the human disorders Parkinson’s disease and mental depression. The chemical synthesis of MIF-1 analogs and isolation of naturally occurring peptides with potent biological activities have yielded a family of Tyr-MIF-1 peptides. Among these, endomorphin-1 and endomorphin-2 show selective agonistic activity for the µ-opiate receptor and therapeutic potential in pain and addiction. Overall, the structural-functional analyses of MIF-1 and other members in this peptide family during the past four decades clearly demonstrate the evolution of the concepts of peptides during our lifetime. This review will summarize some of the concepts, from their initial controversy to widely accepted facts nowadays.

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  1. Blood-Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA

    Weihong Pan & Abba J. Kastin

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  1. Weihong Pan
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  2. Abba J. Kastin
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  1. Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Seiji Shioda M.D., Ph.D. (Professor) (Professor)

  2. Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Ikuo Homma M.D., Ph.D. (Professor) (Professor)

  3. Department of Psychiatry, Karasuyama Hospital, Showa University School of Medicine, 6-11-11, Kitakarasuyama, Setagaya-ku, Tokyo, 157-8577, Japan

    Nobumasa Kato M.D., Ph.D. (Professor) (Professor)

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Pan, W., Kastin, A.J. (2009). Evolution of neuropeptide concepts illustrated by MIF-1 and MSH. In: Shioda, S., Homma, I., Kato, N. (eds) Transmitters and Modulators in Health and Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99039-0_1

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  • DOI: https://doi.org/10.1007/978-4-431-99039-0_1

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