7 Result(s)
within
Aaron M. Rosenfeld
English
-
Article
Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity
Infants and young children are more susceptible to common respiratory pathogens than adults but can fare better against novel pathogens like severe acute respiratory syndrome coronavirus 2. The mechanisms by w...
-
Protocol
Adaptive Immune Receptor Repertoire (AIRR) Community Guide to Repertoire Analysis
Adaptive immune receptor repertoires (AIRRs) are rich with information that can be mined for insights into the workings of the immune system. Gene usage, CDR3 properties, clonal lineage structure, and sequence...
-
Protocol
Adaptive Immune Receptor Repertoire (AIRR) Community Guide to TR and IG Gene Annotation
High-throughput sequencing of adaptive immune receptor repertoires (AIRR, i.e., IG and TR) has revolutionized the ability to carry out large-scale experiments to study the adaptive immune response. Since the m...
-
Protocol
Bulk gDNA Sequencing of Antibody Heavy-Chain Gene Rearrangements for Detection and Analysis of B-Cell Clone Distribution: A Method by the AIRR Community
In this method we illustrate how to amplify, sequence, and analyze antibody/immunoglobulin (IG) heavy-chain gene rearrangements from genomic DNA that is derived from bulk populations of cells by next-generatio...
-
Article
Open AccessAltered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
Differences in immune responses to viruses and autoimmune diseases such as systemic lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are a population of CD11c+T-bet+ B cells crit...
-
Article
Open AccessMaintenance of the human memory T cell repertoire by subset and tissue site
Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that d...
-
Article
An atlas of B-cell clonal distribution in the human body
B-cell VH region repertoire sequencing of eight anatomical sites in six human donors reveals distinct networks of clone distribution.
