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Article
The Role of Receptor Transactivation in the Cardioprotective Effects of Preconditioning and Postconditioning
Analysis of published data indicates that activation of adenosine, opioid, bradykinin, calcitonin gene-related peptide (CGRP), and epidermal growth factor (EGF) receptors plays an important trigger role in isc...
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Article
Opioid Peptide Deltorphin II Simulates the Cardioprotective Effect of Ischemic Preconditioning: Role of δ2-Opioid Receptors, Protein Kinase C, and KATP Channels
The cardioprotective properties of a δ2-opioid receptor agonist deltorphin II were studied in rats with coronary occlusion and reperfusion. Opioid receptor ligands and inhibitors (glybenclamide, chelerythrine, an...
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Article
Activation of k1-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: Role of protein kinase C and KATP channels
Intravenous pretreatment with κ-opioid receptor antagonist (−)-U-50,488 (1 mg/kg) improved heart resistance to the arrhythmogenic effect of coronary occlusion and reperfusion. Selective κ1-opioid receptor antagon...
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Article
Contribution of the Endogenous Opioid System to Regulation of Heart Resistance to the Arrhythmogenic Effect of Short-term Ischemia and Reperfusion
Preliminary selective blockade of µ, δ1, δ2, κ1, and κ2 opioid receptors proved to have no effect on the incidence of ventricular arrhythmias during a 10-min coronary occlusion and subsequent reperfusion in ket-a...
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Article
Stimulation of μ- and δ-Opiate Receptors and Tolerance of Isolated Heart to Oxidative Stress: the Role of NO-Synthase
Preliminary intravenous injection of δ-opiate receptor (OR) agonists DSLET (0.1 mg/kg) or DTLET (0.1 mg/kg) increased tolerance of isolated perfused myocardium to damage by oxidative stress simulated in vivo with...
