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Article
Open AccessEPOCK study protocol: a mixed-methods research program evaluating cancer care coordination nursing occupations in France as a complex intervention
Facing the increasing cancer incidence and cancer survivorship, many national strategic cancer plans have identified cancer care coordination as a priority for health service improvement. However, the high var...
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Article
Multiparametric magnetic resonance imaging for the differentiation of low and high grade clear cell renal carcinoma
To retrospectively evaluate the ability of magnetic resonance (MR) imaging to differentiate low from high Fuhrman grade renal cell carcinoma (RCC).
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Article
Routinely performed multiparametric magnetic resonance imaging helps to differentiate common subtypes of renal tumours
To retrospectively evaluate the ability of multiparametric magnetic resonance (MR) imaging to differentiate renal tumours.
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Article
Ten-year experience of percutaneous image-guided radiofrequency ablation of malignant renal tumours in high-risk patients
To evaluate survival and outcomes after percutaneous radiofrequency ablation (RFA) of malignant renal tumours in high-risk patients with long-term follow-up.
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Article
Phase I and pharmacokinetic study of IV vinflunine in cancer patients with liver dysfunction
Vinflunine is a novel tubulin-targeted agent that is currently indicated as a monotherapy in bladder cancer patients. The recommended dose of 320 mg/m2 is given as an intravenous infusion once every 3 weeks. Vinf...
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Article
Phase I dose-escalation study of oral vinflunine administered once daily for 6 weeks every 8 weeks in patients with advanced/metastatic solid tumours
Vinflunine ditartrate is a microtubule inhibitor belonging to the vinca alkaloid family. This phase I study was carried out to evaluate the maximal tolerated dose, the safety profile, the pharmacokinetics and ...
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Article
Open AccessEverolimus in metastatic renal cell carcinoma patients intolerant to previous VEGFr-TKI therapy: a RECORD-1 subgroup analysis
A relevant percentage of patients with metastatic renal cell carcinoma develop intolerance to vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFr-TKIs) and require careful selection o...
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Article
Stratégie chirurgicale dans les stades localement avancés et métastatiques
Radical nephrectomy with total surgical removal remains the standard treatment for locally advanced renal cell carcinoma (RCC) in 2009. In the majority of cases such surgery is performed via an open route whil...
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Article
Bévacizumab et temsirolimus: quel apport dans la stratégie de prise en charge du cancer du rein métastatique ?
Bevacizumab and temsirolimus are two drugs recently developed and integrated in the first-line therapeutic management of patients with advanced ormetastatic renal cell carcinoma. Bevacizumab, a monoclonal anti...
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Article
Création d’une unité de coordination de la prise en charge des tumeurs rares du rein de l’adulte
The objective of the presented network is to establish a national coordination unit for the management of rare renal cancers in adult patients. This unit has emerged from two French regional multidisciplinary ...
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Article
Nouveautés dans la prise en charge du cancer du rein. Stratégie thérapeutique en 2003
Les nouveautés de l’année 2003 sur le cancer du rein qui peuvent influencer l’évolution de la stratégie thérapeutique ont été :
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Article
Open AccessSubcutaneous interleukin-2, interferon alpha-2b and 5-fluorouracil in metastatic renal cell carcinoma as second-line treatment after failure of previous immunotherapy: a phase II trial
The association of interleukin-2 (IL-2), interferon alpha-2a (IFNα), 5-fluorouracil (5-FU) has been reported to induce response in metastatic renal cell carcinoma (MRCC). This study evaluated IL-2, IFNα and 5FU a...
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Article
Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
Cytokine therapy for cancer or viral diseases is accompanied by the development of depressive symptoms in a significant proportion of patients. Despite the increasing number of studies on the neurotoxic effect...
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Chapter
Vertebral metastases of cancers of unknown primary origin
Cancers of unknown primary origin are cancers that have metastasized but the primary site of which remains obscure when the therapeutic choice has to be made despite clinical examination, laboratory tests, and...
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Chapter
Vertebral metastases of renal cancers
In France, kidney cancer represents 2.1% to 2.6% of cancers in adults with a higher frequency between 50 and 70 years of age and male predominance. It causes 2% of cancer mortality.
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Article
Open AccessGranulocyte-macrophage colony-stimulating factor alone or with dacarbazine in metastatic melanoma: a randomized phase II trial
The potential antitumoural effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) led us to evaluate GM-CSF alone or with dacarbazine (DTIC) in metastatic melanoma in first line randomized phase I...
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Article
Open AccessToxicity and feasibility of adjuvant high-dose interferon alpha-2b in patients with melanoma in clinical oncologic practice
To assess the feasibility and toxicity profile of high-dose interferon alpha-2b (IFN-α-2b) in the adjuvant treatment of patients with cutaneous malignant melanoma outside the reference ECOG 1684 clinical trial...
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Article
In vitro production of human antigen presenting cells issued from bone marrow of patients with cancer
In the prospect of producing autologous antigen presenting cells (APC) to actively immunize patients with cancer against their own tumor we were interested in the in vitro generation of MC and/or dendritic cells....
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Article
Les traitements symptomatiques des douleurs des métastases osseuses vertébrales
Les métastases osseuses sont les causes les plus fréquentes des douleurs chroniques chez les malades cancéreux. Les sites les plus communs sont les vertèbres: 70% sont thoraciques, 20% lombo-sacrées, 10% cervi...
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Article
A phase I trial of repeated tumour-infiltrating lymphocyte (TIL) infusion in metastatic melanoma
The aim of the protocol was to evaluate the side-effects induced by repeated tumour-infiltrating lymphocyte (TIL) infusions in patients with metastatic melanoma (MM). Patients were to receive four TIL infusion...
