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  1. No Access

    Chapter

    Sulfur Conjugates as Putative Pneumotoxic Metabolites of the Pyrrolizidine Alkaloid, Monocrotaline

    Well over 200 pyrrolizidine alkaloids are known, distributed in a number of plant families (Huxtable, 1989; Mattocks, 1986). Important pyrrolizidine-containing families include Crotalaria, Symphytum, Heliotrop...

    R. J. Huxtable, R. Bowers, A. R. Mattocks… in Biological Reactive Intermediates IV (1991)

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    Article

    The toxicity of two synthetic 3-substituted furan carbamates

    Nachweis, dass die verschiedenen Schädigungen in Leber und Lungen von Ratten und Mäusen nach Vergiftung mit einigen Furanosesquiterpen-Naturstoffen mit synthetischem 3-substituiertem Furanderivat nachzuahmen i...

    A. A. Seawright, A. R. Mattocks in Experientia (1973)

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    Article

    Synthetic Compounds with Toxic Properties similar to those of Pyrrolizidine Alkaloids and their Pyrrolic Metabolites

    FOR the first time, some of the toxic effects of unsaturated pyrrolizidine alkaloids on rats have been reproduced by dosing animals with synthetic compounds. Many of the naturally occurring hepatotoxic alkaloi...

    A. R. MATTOCKS in Nature (1971)

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    Article

    Role of the Acid Moieties in the Toxic Actions of Pyrrolizidine Alkaloids on Liver and Lung

    MANY pyrrolizidine alkaloids have toxic effects in the livers and sometimes the lungs of experimental animals1, and there is evidence that these effects are caused by metabolites formed by enzymic dehydrogenation...

    A. R. MATTOCKS in Nature (1970)

  5. Article

    Data for Toxicologists

    Handbook of Analytical Toxicology

    A. R. MATTOCKS in Nature (1970)

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  6. Article

    Iron (II)-Catalysed Conversion of Unsaturated Pyrrolizidine Alkaloid N-Oxides to Pyrrole Derivatives

    ACETIC anhydride causes dehydration of N-oxides of unsaturated pyrrolizidine alkaloid N-oxides to pyrrolelike derivatives1,2. I now report a similar reaction, brought about by ferrous iron (which has previously b...

    A. R. MATTOCKS in Nature (1968)

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    Article

    Toxicity of Pyrrolizidine Alkaloids

    A new class of metabolite, with a pyrrole-like structure, has been demonstrated in the tissues of animals poisoned by pyrrolizidine alkaloids. There is some correlation between the degree of hepato-toxicity an...

    A. R. MATTOCKS in Nature (1968)

  8. No Access

    Article

    Hepatotoxic Activity of Semi-Synthetic Analogues of Pyrrolizidine Alkaloids

    MANY of the natural pyrrolizidine alkaloids isolated from various plants are not only acutely hepatotoxic, but are also able to produce subacute and chronic liver lesions in rats when given in an appropriate s...

    R. SCHOENTAL, A. R. MATTOCKS in Nature (1960)