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  1. No Access

    Article

    Physicochemical Properties of the Original Antidepressant GSB-106 and Development of a Method for the Analysis of GSB-106 Substance

    Studies at the V. V. Zakusov Science Research Institute of Pharmacology have worked on the basis of the β-pleated structure of loop 4 of brain-derived neurotrophic factor (BDNF) to construct its dimeric peptid...

    A. V. Tarasyuk, N. M. Sazonova, A. N. Shumskii… in Pharmaceutical Chemistry Journal (2019)

  2. No Access

    Article

    Synthesis and Biological Properties of a New Dipeptide Mimetic of Brain-Derived Neurotrophic Factor Loop 2**

    A dimeric dipeptide mimetic of brain-derived neurotrophic factor loop 2, bis-(N-hexanoyl-seryl-lysine) hexamethylenediamide or GTS-201, was designed and synthesized. It exhibited neuroprotective activity at conce...

    N. M. Sazonova, A. V. Tarasyuk, A. N. Shumskii… in Pharmaceutical Chemistry Journal (2018)

  3. No Access

    Article

    Synthesis and In Vitro Neuroprotector Activity of Diastereoisomers of a Dimeric Dipeptide Mimetic of Nerve Growth Factor GK-2

    Previously, a dimeric dipeptide mimetic bis-(N-monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2) based on the β-turn of the fourth loop of nerve growth factor was prepared by us, activated TrkA, and e...

    N. M. Sazonova, A. V. Tarasyuk, A. N. Shumskii… in Pharmaceutical Chemistry Journal (2018)

  4. No Access

    Article

    Reaction of 8-chloro-5,7-dinitroquinoline with β-dicarbonyl compounds

    3-(5,7-Dinitroquinolin-8-yl)pentane-2,4-dione, 5-(5,7-dinitroquinolin-8-yl)pyrimidine-2,4,6-trione, and 5-(5,7-dinitroquinolin-8-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione cesium salts have been synthesized by a s...

    I. I. Ustinov, I. V. Blokhin, A. N. Shumskii… in Russian Journal of Organic Chemistry (2017)

  5. No Access

    Article

    Hydride adducts of dinitroquinolines in multicomponent Mannich reaction

    Dinitro derivatives of 8-oxyquinoline, 8-oxyquinaldine, and 3,4-dihydroquinolin-2-one when reacted with NaBH4 form hydride σH-adducts that are involved into a multicomponent Mannich reaction affording pyridoazabi...

    A. Yu. Medvedeva, I. E. Yakunina… in Russian Journal of Organic Chemistry (2011)

  6. No Access

    Article

    Selective reduction of 6-substituted 1,5-dinitro-3-azabicyclo[3.3.1]non-6-enes

    Reduction of 6-substituted 1,5-dinitro-3-azabicyclo[3.3.1]non-6-enes gives either saturated 1,5-diamino-3-azabicyclo[3.3.1]nonane or unsaturated 1,5-diamino-3-azabicyclo[3.3.1]non-6-enes, depending on the cond...

    I. E. Yakunina, A. N. Shchukin, M. V. Kopyshev… in Russian Journal of Organic Chemistry (2011)

  7. No Access

    Article

    Osmoadaptation in Representatives of Haloalkaliphilic Bacteria from Soda Lakes

    The adaptation of microorganisms to life in brines allows two strategies: the accumulation of organic osmoregulators in the cell (as in many moderate halophiles, halomonads in particular) or the accumulation o...

    Yu. V. Boltyanskaya, E. N. Detkova, A. N. Shumskii, L. E. Dulov… in Microbiology (2005)

  8. No Access

    Article

    Synthesis and Structure of 1,9-Dinitro-5-oxa-11-azatricyclo[6.4.0.04,9]dodecan-2-one

    A series of 6,11-disubstituted 1,9-dinitro-5-oxa-11-azatricyclo[6.4.0.04,9 ]dodecan-2-ones were prepared from anionic adducts of 2,4-dinitrophenol with propanone and 2-phenylethanone carbanions by successive sele...

    Yu.M. Atroshchenko, I.V. Shakhkel'dyan… in Russian Journal of Organic Chemistry (2005)

  9. No Access

    Article

    A New Approach to the Synthesis of Dithienylethanediones and Dithienylacetylenes

    1,2-Dithienylethanediones were synthesized by modified acylation of thiophene and its homologs in the presence of aluminum chloride and pyridine. The bishydrazones of the products were converted into dithienyl...

    L. I. Belen'kii, V. Z. Shirinyan, G. P. Gromova… in Chemistry of Heterocyclic Compounds (2003)

  10. No Access

    Article

    Synthesis and Some Chemical Properties of 2,2-Dimethyl-4-R-1-oxa-4-aza-2-sila-5-benzocycloheptanones

    One-pot synthesis of 2,2-dimethyl-4-R-1-oxa-4-aza-2-sila-5-benzocycloheptanones (R = Me, CH2SiMe2Cl) from the N-methylamide of salicylic acid and salicylamide, respectively, by treatment of these amides with a mi...

    O. A. Zamyshlyaeva, A. G. Shipov, E. P. Kramarova… in Chemistry of Heterocyclic Compounds (2002)

  11. No Access

    Article

    Bis(O--Si)-chelate fluorobis(2-oxohexahydroazepinomethyl)silylium tetrafluoroborate, a cation-anionic complex containing a silylium ion stabilized by O→Si coordination

    E. P. Kramarova, S. A. Pogozhikh, A. G. Shipov… in Russian Chemical Bulletin (2001)

  12. No Access

    Article

    Study of an infrasonic generator

    As the result of the tests carried out by us it was established that the electromechanical infrasonic generator provides two sinusoidal voltages, displaced in phase by 90°. The phase angle error between these ...

    Yu. L. Kurkin, N. S. Kurkina, R. D. Matsonashvili, A. N. Shumskii… in Measurement Techniques (1961)