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Open AccessSYT-SSX fusion genes and prognosis in synovial sarcoma
A case series of 64 synovial sarcomas was characterized for the SYT-SSX fusion transcripts and statistically analysed in order to correlate molecular data with prognosis and morphology. SYT-SSX1 fusion transcr...
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Article
Open Accessc-KIT and c-KIT ligand (SCF) in synovial sarcoma (SS): an mRNA expression analysis in 23 cases
In a previous immunophenotypic molecular-based analysis it was shown that bcl2 over-expression characterizes the SS gene profile in addition to the non-random translocations. Here we show that the over-express...
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Article
Open AccessIdentification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma
Synovial sarcoma (SS) is cytogenetically characterized by the translocation t(X;18)(p11.2-q11.2) generating a fusion between the SYT gene on chromosome 18 and one member of the SSX family gene (SSX1; SSX2; SSX...
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Article
Open AccessThe expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma
Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12q13–15, whereas well differentiated liposarcomas (WDL) show supernumerary ring and gian...
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Article
Open AccessEsthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing’s group
Esthesioneuroblastoma (ENB) is a rare, site-specific, locally aggressive neuronal malignancy so far thought to belong to primitive peripheral neuroectodermal tumour-Ewing’s tumour (pPNETs-ETs). Its anatomical ...
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Article
Open Accessc-erbB2/neu gene and chromosome 17 analysis in breast cancer by FISH on archival cytological fine-needle aspirates
The detection of specific genetic alterations in breast cancer is useful for diagnosing, predicting prognosis and planning preoperative treatment. c-erbB2/neu overexpression is usually detected by immunocytochemi...
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Article
Detection of TP53 mutation, loss of heterozygosity and DNA content in fine-needle aspirates of breast carcinoma
Recent preclinical and clinical data suggest that TP53 status and TP53 mutations may be important in determining tumour aggressiveness and therapy response. In this study we investigate the feasibility of a st...
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Article
Cosmid-derived markers anchoring the bovine genetic map to the physical map
The map** strategy for the bovine genome described in this paper uses large insert clones as a tool for physical map** and as a source of highly polymorphic microsatellites for genetic ty**, and was one ...
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Article
Physical map** of connexin 32 (GJB1) and 43 (GJA1) genes to bovine Chromosomes Xq22 and 9q15/16 by fluorescence in situ hybridization
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Article
Chromosomal localization and molecular characterization of 53 cosmid-derived bovine microsatellites
Gene map** in cattle has progressed rapidly in recent years largely owing to the introduction of powerful genetic markers, such as the microsatellites, and through advances in physical map** techniques suc...
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Article
Map** of syntenic groups U7 and U27 to bovine Chromosomes 25 and 12, respectively