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Article
Blast injury model estimates from multiple overpressure measurement locations on a single person-borne device
Towards a better characterization of the increasing blast overpressure threat, person-borne sensors are being considered for large military population segments potentially subjected to explosive blast and firi...
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Article
Effect of Placental Growth Factor on Trophoblast–Endothelial Cell Interactions In Vitro
Placental growth factor (PlGF) is an important angiogenic factor which has an emerging role in the clinical management of suspected preeclampsia. The role of PlGF in normal placental development is not complet...
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Article
Acceleration-based methodology to assess the blast mitigation performance of explosive ordnance disposal helmets
To design the next generation of blast mitigation helmets that offer increasing levels of protection against explosive devices, manufacturers must be able to rely on appropriate test methodologies and human su...
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Article
Open AccessPlacental growth factor and pre-eclampsia
Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports tr...
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Article
Open AccessDiscrepancies in central review re-testing of patients with ER-positive and HER2-negative breast cancer in the OPTIMA prelim randomised clinical trial
There is limited data on results of central re-testing of samples from patients with invasive breast cancer categorised in their local hospital laboratories as oestrogen receptor (ER) positive and human epider...
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Article
Delayed spinal epidural hematoma following spinal anesthesia, far from needle puncture site
Case report.
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Article
Open AccessEvaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast cancer
[18F]fluorothymidine (FLT) has been proposed as a positron emission tomography (PET)-imaging biomarker of proliferation for breast cancer. The aim of this prospective study was to assess the feasibility of FLT-PE...
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Article
Open AccessSimilar effects on cognitive performance during high- and low-carbohydrate obesity treatment
Low-carbohydrate (L-CHO) diets are often used for weight loss but their effects on cognitive function are not well understood. The present study compared the effects of a L-CHO and high-carbohydrate (H-CHO) we...
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Article
Open AccessAdjuvant chemotherapy in older women (ACTION) study – what did we learn from the pilot phase?
The ACTION trial was initiated to provide evidence from a randomised trial on the effects of chemotherapy in women aged over 70 years where evidence for risk and benefit are lacking.
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Article
DNA repair signature is associated with anthracycline response in triple negative breast cancer patients
We hypothesized that a subset of sporadic triple negative (TN) breast cancer patients whose tumors have defective DNA repair similar to BRCA1-associated tumors are more likely to exhibit up-regulation of DNA r...
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Chapter and Conference Paper
A Review of Biaxial Test Methods for Composites
This paper will give an overview of the existing biaxial test methods for composite materials from the early beginning till the currently used methods. An evolution in both the biaxial testing capabilities and...
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Article
Open AccessThe relationship of the neo-angiogenic marker, endoglin, with response to neoadjuvant chemotherapy in breast cancer
Endoglin (CD105) is upregulated in endothelial cells of tissues undergoing neovascularisation. A greater number of CD105-positive vessels predicts poor survival in breast cancer. We examine whether CD105 expre...
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Article
Open AccessNeoadjuvant chemotherapy prior to preoperative chemoradiation or radiation in rectal cancer: should we be more cautious?
Neoadjuvant chemotherapy (NACT) is a term originally used to describe the administration of chemotherapy preoperatively before surgery. The original rationale for administering NACT or so-called induction chem...
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Article
Can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for T3–T4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local recurrence and the appropriateness of local excision?
Local excision is considered inappropriate treatment for T3–T4 rectal adenocarcinomas, as it cannot provide prognostic information regarding lymph node involvement and has a high risk of pelvic recurrence. Pre...
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Article
Open AccessEvaluation of ER, PgR, HER-2 and Ki-67 as predictors of response to neoadjuvant anthracycline chemotherapy for operable breast cancer
Primary systemic therapy (PST) for operable breast cancer enables the identification of in vivo biological markers that predict response to treatment. A total of 118 patients with T2–4 N0–1 M0 primary breast canc...
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Article
Effect of thermal manikin surface temperature on the performance of personal cooling systems
Thermal manikin experiments were carried out to investigate the effect of manikin surface temperature on the performance of a personal cooling system (PCS), more specifically, a liquid circulating garment (LCG...
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Article
Studies of the Potential Utility of Ki67 as a Predictive Molecular Marker of Clinical Response in Primary Breast Cancer
Introduction. Objectives were to characterise the relationship of the proliferation marker Ki67 with response to systemic treatment in early breast cancer and to assess its clinical utility, using fine needle as...
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Chapter
Manipulation of the Expression of Heme Activated Protein HAP5c Gene in Transgenic Plants
To better understand the regulation of respiratory metabolism during hypoxia, we have isolated a gene, HAP5c (Heme Activated Protein), from Arabidopsis thaliana that shows 65% amino acid identity with the yeast H...
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Article
Quantitative changes in cytological molecular markers during primary medical treatment of breast cancer: A pilot study
Aim: To quantify the changes in biological molecular markers during primary medical treatment in patients with operable breast cancer and to assess their possible relationship with response to treatment.
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Article
Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response
Aim: To determine the effects of tamoxifen on the levels of hormone receptors and proliferation markers in the early phase of treatment and the relationship of the changes with tumor response in patients with ...
