5 Result(s)
within
A. M. Schmitt-Verhulst
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Article
RelA regulates the survival of activated effector CD8 T cells
Nuclear factor of kappa B (NF-κB) transcription factors are critical regulators of T-cell activation and survival. The relative contribution of individual NF-κB members to these processes remains elusive. We inve...
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Article
The lack of NF-κB transactivation and PKCε expression in CD4+CD8+ thymocytes correlates with negative selection
Deletion of autoreactive thymocytes at the DP stage is the basis for tolerance to thymus-expressed self antigens. In this study we investigated whether distinct signalling pathways are induced in DP thymocytes...
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Article
Selective destruction by formaldehyde fixation of an H-2Kb serological determinant involving lysine 89 without loss of T-cell reactivity
In preparation for functional analyses, a study of the binding of H-2Kb-specific monoclonal antibodies (mAb) to formaldehyde (FOR)-fixed H-2b spleen or tumor cells revealed that three of nine mAb tested had lost ...
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Article
Interaction between MHC-encoded products and cloned T cells
The interaction between class I major histocompatibility complex (MHC) products and T cells was studied using H-2Kb-specific alloreactive T-cell lines and clones obtained by repeated in vitro stimulation with all...
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Chapter and Conference Paper
Analysis of the Anti-Self + TNP Immune Response: T Cell Lines, Clones and Hybridomas
An immune response induced by the presentation of the hapten trinitrophenyl (TNP) on syngeneic cells can result from in vitro stimulation of T cells with syngeneic cells after trinitrobenzenesulfonate (TNBS) t...
