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Article
Dual Task Performance Is Associated with Amyloidosis in Cognitively Healthy Adults
Preclinical Alzheimer’s disease (AD) provides an opportunity for the study and implementation of interventions and strategies aimed at delaying, mitigating, and preventing AD. While this preclinical state is a...
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Article
Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys
Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An incre...
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Chapter
Efficacy of Intrathecally Administered Natural Human Fibroblast Interferon as Treatment of Multiple Sclerosis
In 1981 we reported the results of an open, preliminary study of 20 patients suggesting that intrathecally (IT) administered natural human fibroblast interferon (IFN-B) reduced the neurologic exacerbations of ...
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Chapter
Clinical Use of Interferons: Central Nervous System Disorders
Interest in the experimental treatment of central nervous system (CNS) disorders has been stimulated by the introduction of interferon (IFN) into clinical use. Presently incurable viral diseases of the brain s...