Skip to main content

and
  1. No Access

    Article

    Multicellular Mathematical Modelling of Mesendoderm Formation in Amphibians

    The earliest cell fate decisions in a develo** embryo are those associated with establishing the germ layers. The specification of the mesoderm and endoderm is of particular interest as the mesoderm is induc...

    L. E. Brown, A. M. Middleton, J. R. King, M. Loose in Bulletin of Mathematical Biology (2016)

  2. No Access

    Article

    Wave pinning and spatial patterning in a mathematical model of Antivin/Lefty–Nodal signalling

    Nodal signals are key regulators of mesoderm and endoderm development in vertebrate embryos. It has been observed experimentally that in Xenopus embryos the spatial range of Nodal signals is restricted by the sig...

    A. M. Middleton, J. R. King, M. Loose in Journal of Mathematical Biology (2013)

  3. No Access

    Article

    Mathematical Modelling of the Aux/IAA Negative Feedback Loop

    The hormone auxin is implicated in regulating a diverse range of developmental processes in plants. Auxin acts in part by inducing the Aux/IAA genes. The associated pathway comprises multiple negative feedback lo...

    A. M. Middleton, J. R. King, M. J. Bennett, M. R. Owen in Bulletin of Mathematical Biology (2010)

  4. No Access

    Article

    Evaluation of a commercial radiometric system for primary isolation of mycobacteria over a fifteen-year period

    The rate of recovery and time to detection of mycobacteria from clinical specimens were analysed for specimens inoculated into both radiometric Middlebrook 7H12 (Bactec 12B, originally 12A) medium and Lowenste...

    A. M. Middleton, M. V. Chadwick, H. Gaya in European Journal of Clinical Microbiology … (1997)