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Article
TOXICAN: a guide for grading dermatological adverse events of cancer treatments
The dermatological toxicity of cancer treatments is frequent and sometimes debilitating. Its reference classification, the NCI-CTCAE (National Cancer Institute–Common Terminology Criteria for Adverse Events), ...
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Article
Open AccessPredictors of responses to immune checkpoint blockade in advanced melanoma
Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, ...
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Article
Development of brain metastases in patients with metastatic melanoma while receiving ipilimumab
Ipilimumab is a monoclonal antibody blocking the inhibitory molecule CTLA4 expressed by activated T lympocytes, used for the treatment of metastatic melanoma. Recent studies have shown its potential efficacy o...
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Article
Incidence and characteristics of melanoma brain metastases develo** during treatment with vemurafenib
Vemurafenib is indicated for the treatment of patients with BRAF V600 -mutant metastatic melanoma. We studied for the first time the characteristics of brain met...
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Article
Anti-inflammatory properties of a new undecyl-rhamnoside (APRC11) against P. acnes
Acne vulgaris is a skin disease affecting pilosebaceous glands in which Propionibacterium acnes (P. acnes) induced inflammation plays a central role. In order to develop new therapies against the inflammatory eve...
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Article
Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1
Although much has been learned in recent years about the apoptotic machinery, the mechanisms underlying survival and death choices during development of metazoans remain less clearly understood. During early o...
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Article
Melanoma gene expression and clinical course
Evidence for the in vitro lymphocyte response against autologous melanoma has been accumulating over the past 10 years, leading to the identification of numerous melanoma-associated antigens recognised by T ce...
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Article
Anti-inflammatory effects of lithium gluconate on keratinocytes: a possible explanation for efficiency in seborrhoeic dermatitis
Topical lithium (Li) gluconate has a beneficial effect on seborrhoeic dermatitis (SD), unlike oral lithium (Li) used in psychiatry. SD is an inflammatory dermatitis associated, in most of cases, with colonizat...
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Article
Modulation of integrins and filaggrin expression by Propionibacterium acnes extracts on keratinocytes
Propionibacterium acnes plays an important role in the pathogenesis of acne and it is established that this bacteria is involved in the induction and maintenance of the inflammatory phase of acne. The aim of our ...
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Article
Loss of oncostatin M receptor β in metastatic melanoma cells
Oncostatin M (OSM) is an interleukin-6 (IL-6) type cytokine originally described by its capacity to inhibit melanoma proliferation in vitro. Here, the mechanisms involved in resistance to growth inhibition by OSM...
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Sézary’s syndrome and human immunodeficiency virus negative Kaposi’s sarcoma