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  1. Article

    Open Access

    Targeted next-generation sequencing of 21 candidate genes in hereditary ovarian cancer patients from the Republic of Bashkortostan

    About 5–10% of all ovarian cancer cases show familial clustering, and some 15–25% of familial ovarian cancer cases are mediated by high-penetrance mutations in the BRCA1 and BRCA2 genes. Only few other genes have...

    D. S. Prokofyeva, E. T. Mingazheva, Ya. V. Valova… in Journal of Ovarian Research (2023)

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  2. No Access

    Article

    The Role of Polymorphic Variants of Several Genes of Matrix Metalloproteinases and Their Tissue Inhibitors in the Development of Gastric Cancer

    The main function of matrix metalloproteinases is the degradation of the extracellular matrix and participation in signal transduction. In addition, it is known that they are involved in all stages of the prog...

    L. F. Gallyamova, A. Kh. Nurgalieva, I. I. Khidiyatov… in Russian Journal of Genetics (2021)

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    Article

    The Role of Allelic Variants of Several Genes of Cytokines in the Development of Gastric Cancer

    Pro- and anti-inflammatory cytokines modulate the inflammatory response in the gastric mucosa. The analysis of associations of allelic variants of cytokine genes in the process of tumorous transformation of th...

    L. F. Yusupova, A. Kh. Nurgalieva, I. R. Gilyazova… in Russian Journal of Genetics (2019)

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    Article

    Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development

    Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. ...

    E. Kh. Shaymardanova, A. Kh. Nurgalieva, I. M. Khidiyatova… in Russian Journal of Genetics (2016)

  5. No Access

    Article

    Association of cytokine gene polymorphisms in peptic ulcer development in the Bashkortostan Republic

    Peptic ulcer disease (PUD) is a chronic disease based on recurrent gastric or duodenal ulcers. Association analysis of common polymorphisms of the cytokines genes IL1B (rs1143634), IL1RN (rs71941886), IL8 (rs4073

    A. Kh. Nurgalieva, E. Kh. Shaymardanova, I. M. Khidiyatova… in Russian Journal of Genetics (2014)