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  1. Article

    Open Access

    Zbtb16 has a role in brown adipocyte bioenergetics

    A better understanding of the processes influencing energy expenditure could provide new therapeutic strategies for reducing obesity. As the metabolic activity of the brown adipose tissue (BAT) and skeletal mu...

    C L Plaisier, B J Bennett, A He, B Guan, A J Lusis, K Reue… in Nutrition & Diabetes (2012)

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  2. No Access

    Article

    A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci

    Understanding the genetics of behavioral variation remains a fascinating but difficult problem with considerable theoretical and practical implications. We used the genome-tagged mice (GTM) and an extensive te...

    G D Gale, R D Yazdi, A H Khan, A J Lusis, R C Davis, D J Smith in Molecular Psychiatry (2009)

  3. Article

    Identification of ALOX5 as a gene regulating adiposity and pancreatic function

    We previously used an integrative genetics approach to demonstrate that 5-lipoxygenase (5-LO) deficiency in mice (Alox5 −/−) protects against atherosclerosis despite increasing lipid levels and ...

    M. Mehrabian, F. T. Schulthess, M. Nebohacova, L. W. Castellani, Z. Zhou… in Diabetologia (2008)

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  4. No Access

    Chapter

    The Functional Consequences of Polymorphisms in the Human PON1 Gene

    Early research on population distributions of plasma PON1 paraoxonase activity indicated a polymorphic distribution with high, intermediate and low metabolizers. Cloning and characterization of the cDNA encodi...

    C.E. Furlong, R.J Richter, W.-F. Li… in The Paraoxonases: Their Role in Disease De… (2008)

  5. No Access

    Article

    Hepatocellular carcinoma in Txnip-deficient mice

    The molecular pathogenesis and the genetic aberrations that lead to the progression of hepatocellular carcinoma (HCC) are largely unknown. Here, we demonstrate that the thioredoxin interacting protein (Txnip) gen...

    S S Sheth, J S Bodnar, A Ghazalpour, C K Thipphavong, S Tsutsumi, A D Tward… in Oncogene (2006)

  6. Article

    Erratum: Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

    Nat. Genet. 37, 1224–1233 (2005). The first sentence of the first paragraph in the Results section should begin, “In the BXD cross, female F2 mice homozygous with respect to the DBA/2J (DBA) allele at the Alox...

    M Mehrabian, H Allayee, J Stockton, P Y Lum, T A Drake, L W Castellani… in Nature Genetics (2005)

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  7. No Access

    Article

    A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse Chromosome 19

    D. E. Tabor, Y. -R. **a, M. Mehrabian, P. A. Edwards, A. J. Lusis in Mammalian Genome (1998)

  8. No Access

    Article

    Assignment of the mouse sterol carrier protein gene (Scp2) to Chromosome 4

    C. L. Welch, Y. -R. **a, J. T. Billheimer, J. F. Strauss, A. J. Lusis in Mammalian Genome (1996)

  9. No Access

    Article

    Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse Chromosome 9

    Y. -R. **a, C. L. Welch, C. H. Warden, E. Lange, T. Fukao, A. J. Lusis… in Mammalian Genome (1996)

  10. No Access

    Article

    Localization of mouse peroxisome proliferator-activated receptor δ (Ppard) on Chromosome 17 near colipase (Clps)

    R. D. Cohen, C. Welch, Y. -R. **a, A. J. Lusis, K. Reue in Mammalian Genome (1996)

  11. No Access

    Article

    The glutathione peroxidase gene, Gpx1, maps to mouse Chromosome 9

    S. Mehdizadeh, C. H. Warden, P. -Z. Wen, Y. -R. **a, M. Mehrabian… in Mammalian Genome (1996)

  12. No Access

    Article

    Assignment of the mouse vesicular monoamine transporter genes, Slcl8al and Slcl8a2, to Chromosomes 8 and 19 by linkage analysis

    A. Roghani, C. Welch, Y. -R. **a, Y. Liu, D. Peter, J. P. Finn… in Mammalian Genome (1996)

  13. No Access

    Article

    Localization of mouse peroxisome proliferator-activated receptor γ on Chromosome 6

    K. Reue, Y. -R. **a, V. W. Shi, R. D. Cohen, C. Welch, A. J. Lusis in Mammalian Genome (1996)

  14. No Access

    Article

    A locus on the X Chromosome is linked to body length in mice

    Linkage between body length (anus to nose (AN) length) and three markers on the mouse X Chromosome was found in an interspecific backcross ((C57BL/6J x Mus spretus) Fl x C57BL/6J), designated BSB. A cross of 409 ...

    A. V. Lembertas, J. S. Fisler, C. H. Warden, P -Z. Wen, Y -R. **a… in Mammalian Genome (1996)

  15. No Access

    Chapter

    Genetics of complex diseases: from mouse to man and back

    Identification of genes underlying complex (non-Mendelian) traits, which include diseases such as IBD, has been an important and difficult problem in genetics. However, new tools and methods have brought on a ...

    C. H. Warden, J. I. Rotter, A. J. Lusis in Inflammatory Bowel Disease (1994)

  16. No Access

    Chapter

    Modified Lipoproteins and Atherogenesis

    A number of studies have shown that oxidized lipoproteins are present in the artery wall and that the amount of oxidized lipid is increased in the atherosclerotic plaque (Palinski et al. 1989; Haberland et al....

    J. A. Berliner, M. Territo, A. Amdalibi… in Cellular and Molecular Biology of Atherosc… (1992)

  17. No Access

    Chapter

    The Low Leukocyte (LLC) Mouse, a Second Model of “Senescence -Accelerated” Amyloidosis Associated with Apolipoprotein All Pro5→GLN; Prevalence of this Substitution Among Inbred Strains of Mice

    The LLC/CKC mouse was developed from a hybrid stock derived by cross-breeding C57BL/6J, C57BR/CdJ, A/J, BALB/cJ, LLC/Ckc and SM/Ckc mice screened for low leukocyte counts (4-5000/mm3) over 22 generations. 100%...

    C. Warden, L. Bee, A. J. Lusis, C. Lerner, C. K. Chai… in Amyloid and Amyloidosis 1990 (1991)

  18. No Access

    Article

    Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

    OXIDIZED lipoproteins have been identified in atherosclerotic plaques1,2 and in early lesions3,4 in humans as well as in animals. There is accumulating evidence that such oxidized lipoproteins have an important r...

    T. B. Rajavashisth, A. Andalibi, M. C. Territo, J. A. Berliner, M. Navab… in Nature (1990)

  19. Article

    APOLIPOPROTEIN B (APO B) GENE IN CONGENITAL DISORDERS OF FAT ABSORPTION

    The aim of the present study was to elucidate whether the great heterogeneity of biochemical lesions responsible for abetalipoproteinemia (ablp) and Anderson's disease (Ad) resulted from different types of gen...

    M Pessah, M E Bouma, I Beucler, L Aggerbeck, A J Lusis, B Leluyer… in Pediatric Research (1989)

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  20. No Access

    Article

    Complete protein sequence and identification of structural domains of human apolipoprotein B

    Epidemiological, pathological and genetic studies show a strong positive correlation between elevated plasma concentrations of low-density lipoprotein (LDL) cholesterol and the risk of premature coronary heart...

    T. J. Knott, R. J. Pease, L. M. Powell, S. C. Wallis, S. C. Rall Jr… in Nature (1986)

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