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Article
Long-term cost-effectiveness of screening for fracture risk in a UK primary care setting: the SCOOP study
Community-based screening and treatment of women aged 70–85 years at high fracture risk reduced fractures; moreover, the screening programme was cost-saving. The results support a case for a screening programm...
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Article
Screening for high hip fracture risk does not impact on falls risk: a post hoc analysis from the SCOOP study
A reduction in hip fracture incidence following population screening might reflect the effectiveness of anti-osteoporosis therapy, behaviour change to reduce falls, or both. This post hoc analysis demonstrates...
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Article
Systematic screening using FRAX® leads to increased use of, and adherence to, anti-osteoporosis medications: an analysis of the UK SCOOP trial
In the large community-based SCOOP trial, systematic fracture risk screening using FRAX® led to greater use of AOM and greater adherence, in women at high fracture risk, compared with usual care.
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Article
Open AccessThe use of percentile-percentile plots to compare differences in seasonal dynamics, illustrated by the case of ground beetles (Coleoptera, Carabidae) reacting to urbanisation
We suggest the use of a graphical method, involving a standardisation of the seasonal activity curves and their subsequent comparison by a percentile-percentile graph as an easy way to compare seasonal activit...
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Article
Open AccessLearning to work together – lessons from a reflective analysis of a research project on public involvement
Patient and public involvement (PPI) in research is very important, and funders and the NHS all expect this to happen. What this means in practice, and how to make it really successful, is therefore an importa...
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Article
A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of screening older women for the prevention of fractures: rationale, design and methods for the SCOOP study
SCOOP is a UK seven-centre, pragmatic, randomised controlled trial with 5-year follow-up, including 11,580 women aged 70 to 85 years, to assess the effectiveness and cost-effectiveness of a community-based scr...
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Chapter and Conference Paper
Testing, Evaluation and Performance of Optimization and Learning Systems
Benchmarks and test suites are widely used to evaluate optimization and learning systems. The advantage is that these test problems provide an objective means of comparing systems. The potential disadvantage i...
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Chapter and Conference Paper
The Traveling Salesrep Problem, Edge Assembly Crossover, and 2-opt
Optimal results for the Traveling Salesrep Problem have been reported on problems with up to 3038 cities using a GA with Edge Assembly Crossover (EAX). This paper first attempts to independently replicate these r...
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Chapter
Aortic and Abdominal Glomera
Firstly, like previous speakers, I would like to pay tribute to John and Hazel Coleridge -both to their seminal research work in the field of cardiovascular receptors, and secondly to them personally. I have k...
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Chapter and Conference Paper
Hypertrophy of Abdominal Vagal Paraganglia Following Chronic Hypoxia: Compared with Carotid Body
The term “abdominal vagal paraganglia” was first coined by Goormaghtigh (1) to describe minute aggregations of so-called “glomus” tissue associated with the abdominal vagus and its branches, which bear a strik...
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Article
Antidiuretic hormone involvement in the release of α-melanocyte-stimulating hormone by hyperosmotic stimuli
In the normal Wistar rat, the plasma α-MSH level was raised by hypertonic saline injection (as compared with control rats injected with isotonic saline). No such rise in α-MSH followed hypertonic saline admini...
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Article
Nerve endings in rat carotid body
The carotid body of the rat consists of “glomera” interspersed by blood vessels and nerve bundles. Each “glomus” consists of 2–12 Type I cells, incompletely invested by 1–3 Type II cells. Type I cells are char...
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Article
Post-natal Development of Rat Pituitary Melanocyte-stimulating Hormone and the Effect of Light
LIGHT influences the level of melanocyte-stimulating hormone (MSH) in the pituitary gland of rats1. The MSH content increases after a period of constant illumination and is lowered by a period of darkness. This r...
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Article
Aorticopulmonary Glomus Tissue in the Cat
HUGHES has recently reported a portal blood supply to aorticopulmonary glomus tissue in the cat1. The pulmonary arterial vasa vasorum, arising from the coronary arteries, form an intramural capillary network in w...
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Article
Arginine and ‘Neurosecretory’ Material in the Pituitary Gland of the Pig
IN a previous publication1, the distribution of arginine as demonstrated histoehemically by an improved Sakaguchi reaction2 was examined in sections of rat pituitary gland. The results were discussed in relation ...
