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  1. No Access

    Article

    Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3

    Impairment of the complex regulatory network of cell death and survival is frequently the reason for therapy resistance of breast cancer cells and a major cause of tumor progression. We established two indepen...

    M Graessmann, B Berg, B Fuchs, A Klein, A Graessmann in Oncogene (2007)

  2. No Access

    Article

    The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect

    We report here for the first time, that the SV40 small t-antigen inhibits mammary gland differentiation during mid-pregnancy and that about 10% of multiparous WAP-SVt transgenic animals develop breast tumors w...

    F Goetz, Y J Tzeng, E Guhl, J Merker, M Graessmann, A Graessmann in Oncogene (2001)

  3. No Access

    Article

    SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors

    We recently established transgenic animals (WAP-SV-T/t) carrying the early coding region of Simian Virus 40 (SV40) under the transcriptional control of the whey acidic milk protein promoter (WAP), which restri...

    Y J Tzeng, C Zimmermann, E Guhl, B Berg, M L Avantaggiati, A Graessmann in Oncogene (1998)