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  1. No Access

    Article

    hMENA11a contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells

    Human Mena (hMENA), an actin regulatory protein of the ENA/VASP family, cooperates with ErbB receptor family signaling in breast cancer. It is overexpressed in high-risk preneoplastic lesions and in primary br...

    P Trono, F Di Modugno, R Circo, S Spada, A Di Benedetto, R Melchionna… in Oncogene (2016)

  2. No Access

    Article

    TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

    Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of recurrences at distant sites and th...

    M Bartucci, R Dattilo, C Moriconi, A Pagliuca, M Mottolese, G Federici… in Oncogene (2015)

  3. No Access

    Article

    ATM kinase activity modulates ITCH E3-ubiquitin ligase activity

    Ataxia Telangiectasia Mutated (ATM) kinase, a central regulator of the DNA damage response, regulates the activity of several E3-ubiquitin ligases, and the ubiquitination-proteasome system is a consistent targ...

    S Santini, V Stagni, R Giambruno, G Fianco, A Di Benedetto, M Mottolese… in Oncogene (2014)

  4. Article

    Open Access

    Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells

    The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing ...

    V Folgiero, S E Di Carlo, G Bon, E P Spugnini, A Di Benedetto… in Cell Death & Disease (2012)

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  5. Article

    Open Access

    miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer

    Micro RNAs (miRs) are small non-coding RNAs aberrantly expressed in human tumors. Here, we aim to identify miRs whose deregulated expression leads to the activation of oncogenic pathways in human gastric cance...

    A Sacconi, F Biagioni, V Canu, F Mori, A Di Benedetto, L Lorenzon… in Cell Death & Disease (2012)

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  6. No Access

    Article

    Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer

    Estrogen effects on mammary epithelial and breast cancer (BC) cells are mediated by the nuclear receptors ERα and ERβ, transcription factors that display functional antagonism with each other, with ERβ acting ...

    O Paris, L Ferraro, O M V Grober, M Ravo, M R De Filippo, G Giurato, G Nassa… in Oncogene (2012)