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Article
Open AccessPhase II study of the PI3K inhibitor BKM120 in patients with advanced or recurrent endometrial carcinoma: a stratified type I–type II study from the GINECO group
Patients with metastatic endometrial carcinoma have a poor prognosis and PIK3CA mutations and amplifications are common in these cancers. This study evaluated the efficacy and safety of the pure PI3K inhibitor...
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Chapter and Conference Paper
Monitoring Swelling Soils in Eastern Paris (France) Through DinSAR and PSI Interferometry: A Synthesis
Swelling soils (below S2) due to volumetric clays changes under various atmospheric dryness and wet climatic conditions, induce small topographic surface displacements and therefore affects and deforms overlyi...
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Article
Évaluation de la réversion par concentré de complexes prothrombiniques et vitamine K des patients porteurs de prothèse valvulaire mécanique admis dans un service d’urgence suite à un accident hémorragique grave
Les accidents hémorragiques graves sous traitement par antivitamine K (AVK) sont fréquents, et la prise en charge initiale est maintenant bien codifiée. Pour les patients porteurs de valve mécanique cardiaque ...
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Article
The role of parenteral nutrition following surgery for duodenal atresia or stenosis
In our institution, some children routinely receive parenteral nutrition (PN) following surgery for duodenal atresia/stenosis, while others do not. Our aim was to compare growth and infection rate between thes...
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Article
Purification and Characterization of an Intracellular β-Glucosidase from Lactobacillus casei ATCC 393
The lactic acid bacterium,Lactobacillus casei, produces an intracellular β-glucosidase when grown on Man-Rogosa-Sharpe (MRS) medium with cellobiose as carbon source. The β-glucosidase activity is produced intrace...
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Article
N-terminal amino acid sequence of mutant strainBrevibacterium sp. adipamidase
The adipamidase of a mutant strainBrevibacterium sp. R312 involved in the degradation of adiponitrile to adipic acid was purified. Its N-terminal amino acid sequence was shown to be identical toBrevibacterium sp.
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Article
Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients
Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients. Nine asthmatic men received an IV infusion of ...
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Article
Incidence of new diabetic patients on dialysis in Piedmont, Italy: Major changes recorded over a 10-year period
Different incidence rates of new diabetic patients on dialysis are reported in various settings; although prevalence of this disease is often considered a marker of acceptance policy, rates are thought to be i...
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Article
Posterior approach to the rectum for treatment of selected benign lesions
Access to lesions in the mid-rectum can be difficult. This report summarizes our experience with a posterior approach to the rectum in 22 men and 13 women, age range 21 to 96 years. Surgical indications includ...
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Article
90th Annual Convention Poster Presentations and Abstracts
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Article
Enzymatic synthesis of N-ε-acyllysines
Chemical synthesis of N-ε-acyllysines on an industrial scale corresponds to new requirements in the surfactant field; only one chemical synthesis process is currently known for this type of molecule. A number ...
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Article
Synthesis of fatty hydroxamic acids catalyzed by the lipase ofMucor miehei
Biotechnological synthesis of a new class of amphiphilic molecules—fatty hydroxamic acids—was carried out using the lipase ofMucor miehei by reacting hydroxyl amine with the fatty acids in their free or methyl es...
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Article
Use of brevibacterium sp 19-derived amidase for the synthesis of hydroxamic fatty acids
Oleylhydroxamic acid (Oleyl HA) was produced by acylation of neutralized hydroxylamine with oleic acid in buffered or in solvent media using the broad-spectrum amidase activity ofBrevibacterium (BB) sp 19 cells.
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Article
Detoxification of cassava pulp using Brevibacterium sp. R312
Brevibacterium sp. strain R312 has an endocellular β-glucosidase, a nitrile hydratase and an amidase that can break down some cyanoglucosides. Nonsterile cassava pulp suspensions were fermented using this strain...
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Article
Natural nitriles and their metabolism
The present work reviews the numerous nitrile compounds that have been isolated from plants and animals. Two kinds of potentially toxic molecules are widespread, namely the cyanogenic glycosides and cyanollpid...
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Article
Endo-rectal repair of rectocele
Rectocele may cause colorectal symptoms particularly difficulty in evacuation. It is readily identified on clinical examination of the perineum but the pathophysiological abnormality can easily be defined by d...
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Chapter and Conference Paper
The amidases from a Brevibacterium strain: Study and applications
In the first part of this paper different microbial enzyme systems able to hydrolyze the true amide function are reviewed, then some enzyme systems are described in detail: aminopeptidases, amidases of Aspergillu...
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Article
Continuous immobilized cell reactor for amide hydrolysis
This article deals with continuous hydrolysis of acrylamide into acrylic acid using the wild-typeBrevibacterium sp. R312 which can hydrolyze all water-soluble amides into their corresponding acids. Biotransformat...
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Article
Exocellular β-glucosidase inducibility in a mutant strain ofCandida wickerhamii derepressed for endocellular β-glucosidase production
Candida wickerhamii produces one endocellular and one exocellular β-glucosidase. Both enzymes are repressed by glucose in the wild-type strain. In the M7 mutant ofC. wickerhamii, which was previously demonstrate...
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Chapter
Allergen Avoidance
Allergen avoidance may be a specific form of therapy. If a patient is shown to be sensitive to an antigen its removal from the environment may result in marked diminution of symptoms. Recently it was shown tha...