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Open AccessPolygenic Risk Score Analysis of Alzheimer’s Disease in Cases without APOE4 or APOE2 Alleles
The We and others have previously shown that polygenic risk score analysis (PRS) has considerable predictive utility for identifying those at high risk of develo** Alzheimer’s disease (AD) with an area under...
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Fludarabine with pharmacokinetically guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients
We hypothesized that IV busulfan (Bu) dosing could be safely intensified through pharmacokinetic (PK-) dose guidance to minimize the inter-patient variability in systemic exposure (SE) associated with body-siz...
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Open AccessReview of antimicrobial administration in cases of proven bacteraemia in adult patients at one London teaching hospital
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Raised C-reactive protein on ICU discharge is not associated with subsequent poor outcome
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Open AccesspGALS performs well in the hands of a medical student
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Plasma C-reactive protein and albumin as predictors of readmission to intensive care
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Vector projection of biomagnetic fields
Biomagnetic measurements are increasingly popular as functional imaging techniques for the non-invasive assessment of electrically active tissue. Although most currently available magnetometers utilise only on...
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Comparison of three roughness function determination methods
Three methods have been used to experimentally determine the roughness function (ΔU +) for several rough surfaces. These include the rotating disk, the towed plate, and the velocity profil...
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Obesity stigmatization and co**: Relation to mental health symptoms, body image, and self-esteem
OBJECTIVE: To create inventories of stigmatizing situations faced by obese people and ways of co** with stigmatization, and to examine how stigma and co** are related to psychological distress in an obese ...
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Irish society of gastroenterology
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Towards an Understanding of Ethical Behaviour in Small Firms
Allthough small business accounts for over 90% of businesses in U.K. and indeed elsewhere, they remain the largely uncharted area of ethics. There has not been any research based on the perspective of small bu...
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The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
Genetic linkage studies place a gene causing early onset familial Alzheimer's disease (FAD) on chromosome 14q24.3 (refs 1–4). Five mutations within the S182 (Presenilin 1: PS–1) gene, which maps to this region, h...
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A case/control study of adult haematological malignancies in relation to overhead powerlines
A population based case control study of adult haematological malignancy and distance from, and magnetic fields associated with, overhead (OH) power lines has been carried out in the North West and Yorkshire r...
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Functional analysis of the 3′-terminal sequence of the maize controlling element (Ac) by internal replacement and deletion mutagenesis
Using deletion analysis of the Ac transposable element, we have shown that replacement of internal sequences from base pairs 181–3559 does not abolish transposition. We have done sequential deletion analysis of t...
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Childhood cancer and overhead powerlines: a case–control study
A case-control study has been carried out to examine the occurrence of childhood cancer in relation to the proximity of overhead power lines to a child's home address at birth and to the calculated magnetic fi...
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Application of pyrolysis gas chromatography to biological materials
The accurate identification of biological specimens is one of the basic requirements of pure and applied biology. Pyrolysis — GLC offers the possibility of rapid recognition of a specific biochemical compositi...
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Ultrastructure of tissue disintegration and host reactions in potato tubers infected byErwinia carotovora var.atroseptica
An electron microscope study has shown that the spread ofErwinia through potato tuber tissue occurs primarily via the intercellular spaces of the storage parenchyma. Restricted infection of the xylem and phloem e...
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Ultrastructure of entry and spread ofErwinia carotovora var.atroseptica into potato tubers
Bacterial entry into potato tubers through wounds and lenticels was affected by the environment, especially by the prevailing relative humidity. Light and electron microscope examination of tubers inoculated with
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Rapid Diagnosis of Viral and Fungal Diseases in Plants by Pyrolysis and Gas-Liquid Chromatography
WE have approached the diagnosis of plant diseases using a technique similar to that used by Reiner and Ewing1 in recognizing strains of Escherichia coli. This involved analysing thin transverse sections of leaf ...
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An Improved Diphenylamine Method for the Estimation of Deoxyribonucleic Acid
Many plant tissues contain very low levels of DNA and in such circumstances it is necessary to utilize a method of estimation of extreme sensitivity coupled with a low reagent blank. In this respect it is our ...