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    Article

    P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells

    We investigated the expression of P2X4 and P2X6 receptors on human umbilical vein endothelial cells (HUVECs) and found that both P2X receptor subtypes on plasma membranes are largely restricted to areas of cell-...

    R. Glass, A. Loesch, P. Bodin, G. Burnstock in Cellular and Molecular Life Sciences (2002)

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    Article

    Electron-immunocytochemical localization of P2X1 receptors in the rat cerebellum

    The distribution of the P2X1 subtype of purinoceptors associated with the extracellular activities of ATP was studied in the rat cerebellum at the electron-microscope level. Receptors were labelled with peroxidas...

    A. Loesch, Geoffrey Burnstock in Cell and Tissue Research (1998)

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    Article

    CYFRA 21-1 serum levels in women with adnexal masses and inflammatory diseases

    The aim of the present study was to evaluate the clinical usefulness of the cytokeratin marker CYFRA 21-1 as a screening marker for ovarian cancer, as a predictive marker in patients with adnexal masses and as...

    C Tempfer, L Hefler, H Heinzl, A Loesch, G Gitsch, H Rumpold in British Journal of Cancer (1998)

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    Article

    Perivascular nerve fibres and endothelial cells of the rat basilar artery: immuno-gold labelling of antigenic sites for type I and type III nitric oxide synthase

    Ultrastructural localisation of type I (neuronal) and type III (endothelial) isoforms of nitric oxide synthase in perivascular nerve fibres (axons) and endothelial cells was studied in the Wistar rat cerebral ...

    A. Loesch, G. Burnstock in Journal of Neurocytology (1998)

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    Article

    Neuropeptide Y-immunoreactive intracardiac neurones, granule-containing cells and nerves associated with ganglia and blood vessels in rat and guinea-pig heart

    Intrinsic neuropeptide Y-containing neurones in rat and guinea-pig hearts were studied at the ultrastructural level by the pre-embedding peroxidase-antiperoxidase immunocytochemical technique. Intracardiac neu...

    A. A. Sosunov, C. J. S. Hassall, A. Loesch, M. Turmaine in Cell and Tissue Research (1997)

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    Article

    Immunoreactivity for nitric oxide synthase and endothelin in the coronary and basilar arteries of renal hypertensive rats

    The ultrastructural localization of immunoreactivity to nitric oxide synthase (type-III and type-II) and endothelin-1 was examined by using pre-embedding peroxidase-antiperoxidase techniques in the coronary an...

    M. Shochina, A. Loesch, A. Rubino, S. Miah, G. Macdonald in Cell and Tissue Research (1997)

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    Article

    Nitric oxide synthase-containing neurones and nerve fibres within cardiac ganglia of rat and guinea-pig: an electron-microscopic immunocytochemical study

    The nitric oxide synthase-immunoreactivity and NADPH-diaphorase activity of intracardiac neurones in the rat and guinea-pig was studied at the ultrastructural level. While some nitric oxide synthase-containing...

    A. A. Sosunov, C. J. S. Hassall, A. Loesch, M. Turmaine in Cell and Tissue Research (1996)

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    Article

    Electron-microscopic immunolabelling of vasoactive substances in human umbilical endothelial cells and their actions in early and late pregnancy

    Human umbilical vessels are devoid of nerves and therefore endothelial cells may play an important role in the control of feto-placental blood flow. The pharmacological effects of 5-hydroxytryptamine, histamin...

    A. J. Sexton, A. Loesch, M. Turmaine, S. Miah, G. Burnstock in Cell and Tissue Research (1996)

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    Article

    Ultrastructural localization of nitric oxide synthase and endothelin in rat pulmonary artery and vein during postnatal development and ageing

    The ultrastructural distribution of nitric oxide synthase (neuronal isoform, type I) and endothelin immunoreactivity was examined in the develo** and ageing male Wistar rat pulmonary artery and vein. This st...

    A. Loesch, G. Burnstock in Cell and Tissue Research (1996)

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    Article

    Ultrastructural study of perivascular nerve fibres and endothelial cells of the rat basilar artery immunolabelled with monoclonal antibodies to neuronal and endothelial nitric oxide synthase

    The ultrastructural distribution of neuronal (type I) and endothelial (type III) isoforms of nitric oxide synthase in perivascular axons and endothelial cells was examined in the Wistar rat cerebral basilar ar...

    A. Loesch, G. Burnstock in Journal of Neurocytology (1996)

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    Article

    Ultrastructural investigation of nitric oxide synthase-immunoreactive nerves associated with coronary blood vessels of rat and guinea-pig

    Ultrastructural investigation of nitrix oxide synthase-immunoreactive nerves closely associated with blood vessels in rat and guinea-pig hearts revealed many labelled nerve fibres in the walls of the main bran...

    A. A. Sosunov, C. J. S. Hassall, A. Loesch, M. Turmaine in Cell and Tissue Research (1995)

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    Article

    Ultrastructural localization of nitric oxide synthase and endothelin in coronary and pulmonary arteries of newborn rats

    This is the first report on the ultrastructural distribution of nitric oxide synthase and endothelin immunoreactivities in the coronary and pulmonary arteries of newborn Wistar rats. The distribution of nitric...

    A. Loesch, G. Burnstock in Cell and Tissue Research (1995)

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    Article

    An ultrastructural study of NADPH-diaphorase and nitric oxide synthase in the perivascular nerves and vascular endothelium of the rat basilar artery

    This is the first report on the ultra structural distribution of nicotinamide adenine dinucleotide phosphate-diaphorase activity and neuronal isoform (Type I) of nitric oxide synthase immunoreactivity in periv...

    A. Loesch, A. Belai, G. Burnstock in Journal of Neurocytology (1994)

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    Article

    Localization of neuropeptide Y and atrial natriuretic peptide in the endothelial cells of human umibilical blood vessels

    The localization of neuropeptide Y (NPY) and atrial natriuretic peptide (ANP) in the endothelial cells of human umbilical blood vessels was studied using the pre-embedding peroxidase-antiperoxidase (PAP) techn...

    W. Q. Cai, P. Bodin, A. Sexton, A. Loesch, G. Burnstock in Cell and Tissue Research (1993)

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    Article

    Localization of arginine-vasopressin in endothelial cells of rat pulmonary artery

    The localization of arginine-vasopressin in the endothelial cells of rat pulmonary artery was investigated by immunocytochemistry at the light and electron microscopic levels. The immunogold silver staining me...

    A. Loesch, A. Tomlinson, G. Burnstock in Anatomy and Embryology (1991)

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    Article

    An immunohistochemical study of endothelial cell heterogeneity in the rat: observations in “en face” Häutchen preparations

    “En face” sheets of endothelium, in which cellular spatial relationships were maintained, were prepared from proximal pulmonary and femoral arteries and aortae of the Wistar rat, in order to visualise patterns...

    A. Tomlinson, H. Van Vlijmen, A. Loesch, G. Burnstock in Cell and Tissue Research (1991)

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    Article

    Localization of vasopressin, serotonin and angiotensin II in endothelial cells of the renal and mesenteric arteries of the rat

    The localization of vasopressin, serotonin and angiotensin II in the endothelial cells of renal and mesenteric arteries was investigated using the pre-embedding peroxidase-antiperoxidase technique for electron...

    J. Lincoln, A. Loesch, G. Burnstock in Cell and Tissue Research (1990)

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    Article

    The hypothalamo-neurohypophysial system in streptozotocin-diabetic rats: ultrastructural and immunocytochemical evidence for alterations of oxytocin- and vasopressin-containing neuronal profiles

    The hypothalamic paraventricular and supraoptic nuclei and the neurohypophysis of rats were investigated 8 weeks after streptozotocin (STZ)-induction of type I diabetes. Vasopressin (VP)- and oxytocin (OT)-con...

    A. Loesch, J. Lincoln, G. Burnstock in Acta Neuropathologica (1988)

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    Article

    Ultrastructural localisation of serotonin and substance P in vascular endothelial cells of rat femoral and mesenteric arteries

    An electron microscopic-immunocytochemical study has been made on the localisation of serotonin and substance P in endothelial cells of femoral and mesenteric arteries of the rat. In the femoral and mesenteric...

    A. Loesch, G. Burnstock in Anatomy and Embryology (1988)

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    Article

    Enteric nerves in diabetic rats: Electron microscopic evidence for neuropathy of vasoactive intestinal polypeptide-containing fibres

    Enteric nerves in the ileum of rats 8 weeks after streptozotocin-induction of diabetes were examined under the electron microscope before and after immunolabeling for vasoactive intestinal polypeptide (VIP). T...

    A. Loesch, A. Belai, J. Lincoln, G. Burnstock in Acta Neuropathologica (1986)