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within A Graessmann Remove this filter Oncology Remove this filter

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  1. No Access

    Article

    Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3

    Impairment of the complex regulatory network of cell death and survival is frequently the reason for therapy resistance of breast cancer cells and a major cause of tumor progression. We established two indepen...

    M Graessmann, B Berg, B Fuchs, A Klein, A Graessmann in Oncogene (2007)

  2. No Access

    Article

    The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect

    We report here for the first time, that the SV40 small t-antigen inhibits mammary gland differentiation during mid-pregnancy and that about 10% of multiparous WAP-SVt transgenic animals develop breast tumors w...

    F Goetz, Y J Tzeng, E Guhl, J Merker, M Graessmann, A Graessmann in Oncogene (2001)

  3. No Access

    Article

    SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors

    We recently established transgenic animals (WAP-SV-T/t) carrying the early coding region of Simian Virus 40 (SV40) under the transcriptional control of the whey acidic milk protein promoter (WAP), which restri...

    Y J Tzeng, C Zimmermann, E Guhl, B Berg, M L Avantaggiati, A Graessmann in Oncogene (1998)

  4. No Access

    Chapter and Conference Paper

    The Biological Activity of Early SV40 Antisense RNA and DNA Molecules

    It is of basic and applied scientific interest to develop reliable techniques which allow the down regulation of single genes either in isolated cells or in cells of an intact organism. Such an approach should...

    M. Graessmann, A. Graessmann in Transforming Proteins of DNA Tumor Viruses (1989)