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Open AccessErratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs
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Open AccessThe LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs
LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $${1.4 \t...
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ERG rearrangement and protein expression in the progression to castration-resistant prostate cancer
Approximately half of the prostate carcinomas are characterized by a chromosomal rearrangement fusing the androgen-regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG. Aim of this study was to co...
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miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT
Src tyrosine kinase (Src) is implicated in the development of bone metastasis and castration resistance of prostate cancer. Src inhibitors are currently being tested in clinical trials for such diseases. Under...
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Anterior tumors of the prostate: clinicopathological features and outcomes
To determine whether prostate cancers detected in the anterior vs posterior zones impact clinicopathological features and patient outcomes. This information could potentially affect clinical management.
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Erratum: Elevated osteonectin/SPARC expression in primary prostate cancer predicts metastatic progression
Correction to: Prostate Cancer and Prostatic Diseases (2012) 15, 150–156; doi:10.1038/pcan.2011.61; published online 29 November 2011 In this article, published online 29 November 2011, the seventh author's na...
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Elevated osteonectin/SPARC expression in primary prostate cancer predicts metastatic progression
The majority of prostate cancers (CaP) are detected in early stages with uncertain prognosis. Therefore, an intensive effort is underway to define early predictive markers of CaP with aggressive progression ch...
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ERG protein expression and genomic rearrangement status in primary and metastatic prostate cancer—a comparative study of two monoclonal antibodies
Overexpression of the ERG protein is highly prevalent in prostate cancer (PCa) and commonly results from gene fusions involving the ERG gene. Recently, N-terminal epitope-targeted mouse and a C-terminal epitop...
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Prostate cancer gene expression signature of patients with high body mass index
The goal of this study was to evaluate prostate cancer gene expression signatures associated with elevated body mass index (BMI). Global gene expression profiles of prostate tumor cells and matching normal epi...
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Open AccessERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification
Gene fusions prevalent in prostate cancer (CaP) lead to the elevated expression of the ERG proto-oncogene. ERG activation present in 50–70% of prostate tumors underscores one of the most common oncogenic alterati...
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Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells
Annexin-A7 (ANXA7) tumor suppressor role has been shown in various tumors, and ANXA7 expression has been particularly lost in androgen-resistant prostate cancers. In this study, we studied ANXA7 regulation in ...
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TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation
The high prevalence of TMPRSS2-ERG rearrangements (∼60%) in prostate cancer (CaP) leads to androgenic induction of the ETS-related gene (ERG) expression. However, the biological functions of ERG overexpression in...
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Transcriptome analyses of benign and malignant prostate epithelial cells in formalin-fixed paraffin-embedded whole-mounted radical prostatectomy specimens
Formalin-fixed paraffin-embedded (FFPE) prostate specimens are rich sources of molecular pathological information. However, FFPE-based microarray analysis of tissue samples may be hampered by the degradation a...
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Erratum: Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome
Correction to:Oncogene (2005) 24, 3847–3852. doi:10.1038/sj.onc.1208518;published online 7 March 2005 Since the publication of the above manuscript, the authors have identified an error in the author list; the...
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Androgen receptor and prostate cancer
Since the original observations of Huggins and Hodges that prostate cancers are androgen dependent, androgen ablation therapy has been the gold standard for the treatment of advanced prostate cancer (CaP). And...
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Characterization of the androgen receptor in a benign prostate tissue-derived human prostate epithelial cell line: RC-165N/human telomerase reverse transcriptase
The majority of prostate epithelial cell lines stably expressing wild-type (wt) or mutant (mt) androgen receptor (AR) are derived from metastatic prostate cancers. Therefore, the wt AR-expressing RC-165N/human...
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Androgen receptor mutation (T877A) promotes prostate cancer cell growth and cell survival
Alteration of the AR functions due to amplification, overexpression and somatic mutation of the AR itself or altered interaction of AR with other cell growth regulatory proteins, may contribute to a significan...
