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Article
A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties
The LKB1 tumor suppressor gene encodes a master kinase that coordinates the regulation of energetic metabolism and cell polarity. We now report the identification of a novel isoform of LKB1 (named ΔN-LKB1) that i...
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Article
Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1
LKB1 is a tumor suppressor that is constitutionally mutated in a cancer-prone condition, called Peutz-Jeghers syndrome, as well as somatically inactivated in a sizeable fraction of lung and cervical neoplasms. Th...