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    Article

    A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties

    The LKB1 tumor suppressor gene encodes a master kinase that coordinates the regulation of energetic metabolism and cell polarity. We now report the identification of a novel isoform of LKB1 (named ΔN-LKB1) that i...

    R Dahmani, P-A Just, A Delay, F Canal, L Finzi, C Prip-Buus, M Lambert in Oncogene (2015)

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    Article

    Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1

    LKB1 is a tumor suppressor that is constitutionally mutated in a cancer-prone condition, called Peutz-Jeghers syndrome, as well as somatically inactivated in a sizeable fraction of lung and cervical neoplasms. Th...

    H Gaude, N Aznar, A Delay, A Bres, K Buchet-Poyau, C Caillat, A Vigouroux in Oncogene (2012)