3 Result(s)
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A Comino
Drug Resistance
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Article
Open AccessIdentification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer
The transforming growth factor-beta (TGF- β) pathway has been implicated in proliferation, migration and invasion of various cancers. Endoglin is a TGF-β accessory receptor that modulates signalling. We identifie...
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Article
Open AccessNT5E CpG island methylation is a favourable breast cancer biomarker
Relapse risk assessment and individual treatment recommendations remain suboptimal for breast cancer patients. In the light of existing preclinical and clinical data, we studied NT5E (5′-nucleotidase, ecto) expre...
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Article
Open AccessHigh frequency of complex TP53 mutations in CNS metastases from breast cancer
Brain metastasis from breast cancer is usually associated with a poor prognosis and early death. Alteration of p53 may contribute to malignant progression by abrogation of apoptosis induced by oncogene activat...
