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  1. No Access

    Article

    DRR drives brain cancer invasion by regulating cytoskeletal-focal adhesion dynamics

    Malignant glioma invasion is a primary cause of brain cancer treatment failure, yet the molecular mechanisms underlying its regulation remain elusive. We developed a novel functional-screening strategy and ide...

    P U Le, A Angers-Loustau, R M W de Oliveira, A Ajlan, C L Brassard, A Dudley… in Oncogene (2010)

  2. No Access

    Article

    Inhibition of medulloblastoma cell invasion by Slit

    Invasion of brain tumor cells has made primary malignant brain neoplasms among the most recalcitrant to therapeutic strategies. We tested whether the secreted protein Slit2, which guides the projection of axon...

    T E Werbowetski-Ogilvie, M Seyed Sadr, N Jabado, A Angers-Loustau, N Y R Agar… in Oncogene (2006)

  3. No Access

    Article

    E6/E7 oncogenes increase and tumor suppressors decrease the proportion of self-renewing neural progenitor cells

    Many if not most tissues need a controlled number of stem cells to maintain normal function. Cancer can be seen as a process of disturbed tissue homeostasis, in which too many cells have or acquire too primiti...

    K Piltti, L Kerosuo, J Hakanen, M Eriksson, A Angers-Loustau, S Leppä… in Oncogene (2006)