-
Article
Tumour vasculature at single-cell resolution
Tumours can obtain nutrients and oxygen required to progress and metastasize through the blood supply1. Inducing angiogenesis involves the sprouting of established vessel beds and their maturation into an organiz...
-
Article
Metal complexes of bipyridine-functionalized covalent organic frameworks as efficient electrocatalysts for oxygen evolution reaction
Electrocatalytic water splitting is considered a clean and practical method for producing energy. In this study, COF-Bpy, a bipyridine-functionalized covalent organic framework (COF), was prepared via post-syn...
-
Article
Open AccessEffects of perineal massage at different stages on perineal and postpartum pelvic floor function in primiparous women: a systematic review and meta-analysis
Perineal massage, as a preventive intervention, has been shown to reduce the risk of perineal injuries and may have a positive impact on pelvic floor function in the early postpartum period. However, there is ...
-
Article
Chinese Healthy Eating Index (CHEI) and risk of diabetes in Chinese adults: a prospective cohort study
The Chinese Healthy Eating Index (CHEI) is a valid instrument to assess the diet quality of the Chinese population, but evidence regarding the relationship between CHEI and the risk of diabetes remains limited...
-
Article
Open AccessOutcomes of pregnancies complicated by cirrhosis: a retrospective cohort study
Although pregnancy complicated by liver cirrhosis is rare, women with cirrhosis experience increased adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in women with liver cirrhosis an...
-
Article
Open AccessEffects of propofol versus sevoflurane on surgical field visibility during arthroscopic rotator cuff repair: a randomized trial
During arthroscopic rotator cuff repair (ARCR), clear surgical field visibility (SFV) is the basis of successful surgery, but the choice of anesthesia maintenance drugs may have different effects on SFV. In th...
-
Article
Open AccessBET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition
-
Article
Open AccessThe role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control
Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a...
-
Article
Open AccessDepletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte
Psoriasis is a common and recurrent inflammatory skin disease characterized by inflammatory cells infiltration of the dermis and excessive proliferation, reduced apoptosis, and abnormal keratosis of the epider...
-
Article
Open AccessIgneous meteorites suggest Aluminium-26 heterogeneity in the early Solar Nebula
The short-lived radionuclide aluminium-26 (26Al) isotope is a major heat source for early planetary melting. The aluminium-26 – magnesium-26 (26Al-26Mg) decay system also serves as a high-resolution relative chro...
-
Article
Carbonate record of temporal change in oxygen fugacity and gaseous species in asteroid Ryugu
The Hayabusa2 spacecraft explored asteroid Ryugu and brought its surface materials to Earth. Ryugu samples resemble Ivuna-type (CI) chondrites—the most chemically primitive meteorites—and contain secondary phy...
-
Article
Open AccessHOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis
Macrophage-like transformation of vascular smooth muscle cells (VSMCs) is a risk factor of atherosclerosis (AS) progression. Transcription factor homeobox A1 (HOXA1) plays functional roles in differentiation a...
-
Article
Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis
-
Article
Association of urinary metal levels with metabolic syndrome in coal workers
Studies have indicated that metal exposure is associated with an increased risk of metabolic syndrome (MetS). However, it is unclear whether overexposure to heavy metals occurs in miners and is associated with...
-
Article
Open Accessg-C3N4-based photocatalysts for organic pollutant removal: a critical review
With rapid global industrialization, environmental pollution has become one of the major problems of human society. Photocatalysis can be applied to solve environmental problem by using inexhaustible solar ene...
-
Article
A Tiered Ecological Risk Assessment of Caffeine by Using Species Sensitivity Distribution Method in the Nansi Lake Basin
Caffeine has been reported toxic to aquatic organisms, and it frequently occurs at relatively high concentrations in most of surface waters. However, it is difficult to control caffeine pollution because of th...
-
Article
Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis
Initial analyses showed that asteroid Ryugu’s composition is close to CI (Ivuna-like) carbonaceous chondrites (CCs) – the chemically most primitive meteorites, characterized by near-solar abundances for most e...
-
Article
Open AccessBET inhibitors synergize with sunitinib in melanoma through GDF15 suppression
Targeting bromodomain and extra-terminal domain (BET) proteins has shown a promising therapeutic effect on melanoma. The development of strategies to better kill melanoma cells with BET inhibitor treatment may...
-
Article
Cloning and expression of recombinant human superoxide dismutase 1 (hSOD1) in Bacillus subtilis 1012
We aimed to clone and express the human Cu, Zn superoxide dismutase (hSOD1) in Bacillus subtilis 1012. Also, we investigated the expression level of hSOD1 under different induction conditions.
-
Article
Open AccessZebrafish: an efficient vertebrate model for understanding role of gut microbiota
Gut microbiota plays a critical role in the maintenance of host health. As a low-cost and genetically tractable vertebrate model, zebrafish have been widely used for biological research. Zebrafish and humans s...
