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Article
Open AccessPhillyrin reduces ROS production to alleviate the progression of intervertebral disc degeneration by inhibiting NF-κB pathway
Intervertebral disc degeneration (IDD) is an increasingly important cause of low back pain (LBP) that results in substantial health and economic burdens. Inflammatory pathway activation and the production of r...
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Chapter and Conference Paper
Study on Simulated Adsorption of Two Kinds of Biochar on Different Degradable Microplastics
The harm of microplastics (MPs) has been widely confirmed, but there are various problems in the existing removal technology. In this study, two kinds of biochar were used to simulate the adsorption of non-deg...
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Article
Open AccessSchistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D
Macrophages and neutrophils are rapidly recruited around Schistosome eggs to form granulomas. Extracellular traps (ETs) of macrophages and neutrophils are part of the pathogen clearance armamentarium of leukocyte...
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Article
An efficient memristive alternating crossbar array and the design of full adder
Memristor is one of the most promising emerging technologies to solve the von Neumann bottleneck problem due to its non-volatile and binary characteristics. This paper studies the design method of high-efficie...
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Article
The prognostic value of systemic immune-inflammation index in patients with aneurysmal subarachnoid hemorrhage: a systematic review
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating and life-threatening stroke subtype, that has a high disability and fatality rate. By the use of the systemic immune-inflammation index (SII), it is p...
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Article
Open AccessComprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma
Postoperative recurrence and metastasis are the main reasons for the poor prognosis of osteosarcoma (OS). Currently, an ideal predictor for not only prognosis but also drug sensitivity and immunotherapy respon...
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Article
Open AccessSETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair
Cisplatin is commonly used to treat cervical cancer while drug resistance limits its effectiveness. There is an urgent need to identify strategies that increase cisplatin sensitivity and improve the outcomes o...
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Article
Open AccessTAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo
Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pu...
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Article
Open AccessHierarchical porous ECM scaffolds incorporating GDF-5 fabricated by cryogenic 3D printing to promote articular cartilage regeneration
In recent years, there has been significant research progress on in situ articular cartilage (AC) tissue engineering with endogenous stem cells, which uses biological materials or bioactive factors to improve ...
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Article
Changes of Gut Microbiota in Autism Spectrum Disorders and Common Probiotics & Chinese Herbal Medicine Therapeutic Mechanisms: a Review
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that often occurs in children and seriously affects daily life. In recent years, many studies have shown that intestinal microbial imbalance and ...
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Article
Open AccessGenome-wide identification and expression profiling analysis of maize AP2/ERF superfamily genes reveal essential roles in abiotic stress tolerance
As one of the largest transcription factor families in plants, the APETALA2/Ethylene-Responsive Factor (AP2/ERF) superfamily is involved in various biological processes and plays significant roles in plant gro...
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Article
Open AccessPositive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasis
Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal cell carcinoma (ccRCC). PVT1 is an important oncogenic lncRNA which has critical effects on onset...
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Article
Investigation on drug entrapment location in liposomes and transfersomes based on molecular dynamics simulation
In this study, liposome and transfersome were successfully constructed using molecular dynamics simulation. Three drugs with different polarity, including 5-fluorouracil, ligustrazine, and osthole, were select...
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Article
Functional Characteristics and Application of Mesenchymal Stem Cells in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a rare, heterogeneous autoimmune and autoinflammatory disease that affects both sexes and all races, although this disease exhibits its highest incidence/prevalence among ...
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Article
Open AccessEvaluating the effectiveness of a CRSCE-based de-escalation training program among psychiatric nurses: a study protocol for a cluster randomized controlled trial
The high incidence of workplace violence (WPV) in clinical mental health settings has caused a series of negative impacts on nurses, which has subsequently increased public concern. De-escalation (DE) is recom...
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Article
Injuries of the upper cervical spine—how can instability be identified?
The diagnosis of instability of the injured upper cervical spine remains controversial, due to its complicated anatomical configuration and biomechanical property. Since identifying unstable injuries of the up...
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Article
The Application of Coarse-Grained Molecular Dynamics to the Evaluation of Liposome Physical Stability
Physical stability is one of critical characteristics of liposome, especially to its clinical application. Vesicle fusion was one of the common physical stability phenomena that occurred during the long storag...
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Article
Entwicklung eines neuen Protokolls zur präklinischen Immobilisation der Wirbelsäule bei Kindern und erste Anwendungsuntersuchung
Um Sekundärschäden zu vermeiden, stellt die Immobilisation der potenziell verletzten Wirbelsäule eine Standardmaßnahme im präklinischen Traumamanagement dar. Immobilisationsprotokolle sollen dem notfallmedizin...
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Article
Heterogeneous impact of type 2 diabetes mellitus-related genetic variants on gestational glycemic traits: review and future research needs
Gestational glucose homeostasis influences mother’s metabolic health, pregnancy outcomes, fetal development and offspring growth. To understand the genetic roles in pregnant glucose metabolism and genetic pred...
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Article
Open AccessPES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERα/ERβ protein ratio
PES1, a BRCT domain-containing protein, has been shown to play a role in modulating the balance and ratio between ERα and ERβ protein, which is involved in the occurrence and development of breast and ovarian ...
