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Functional Characteristics and Application of Mesenchymal Stem Cells in Systemic Lupus Erythematosus

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Systemic lupus erythematosus (SLE) is a rare, heterogeneous autoimmune and autoinflammatory disease that affects both sexes and all races, although this disease exhibits its highest incidence/prevalence among the black population and shows a predilection for women of reproductive age. Although SLE has no cure, treatment can help decrease its signs and symptoms. Thus, we should focus primarily on personalized treatment. Mesenchymal stem/stromal cells (MSCs), which are multipotent cells capable of differentiating into osteoblasts, chondrocytes, adipocytes, and myoblasts, among other cell types, are potential candidates for use in a promising strategy to treat severe and refractory SLE. MSCs have an immunomodulatory function that can suppress the proliferation and activities of many immune cells, such as T lymphocytes, B lymphocytes, natural killer cells, macrophages and dendritic cells. Substantial progress has recently been made in MSC therapy, and experimental and clinical data suggest that such a therapy is a promising strategy for the treatment of severe and refractory SLE. In this review, we highlight the effects of MSCs on different immune cell types, describe the mechanisms underlying MSC-mediated immunoregulation, and discuss the treatment of SLE with MSCs from different sources in various animal models and clinical applications.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (Grant No. 81600111 and 81600112), the Science and Technology Planning Project of Guangdong Province, China (Grant No. 2017A020215186 and 2016A020215045), the Medical Science and Technology Foundation of Guangdong Province, China (Grant No. A2016175), and the Science and Technology Planning Project of Guangzhou, China (Grant No. 201707010004, 201604020128 and 201607010326).

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Authors and Affiliations

  1. Department of Pediatrics, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, China

    Wen-Yan Tang, Chun-** Peng, Jie-Si Luo, Yan-Lai Tang & Xue-Qun Luo

  2. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, China

    Jia-Hua Liu, Yao Liao & ** Sun

  3. Key Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, 510080, Guangdong, China

    Jia-Hua Liu, Yao Liao & ** Sun

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  1. Wen-Yan Tang
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  2. Jia-Hua Liu
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  3. Chun-** Peng
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  4. Yao Liao
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  5. Jie-Si Luo
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  6. ** Sun
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  7. Yan-Lai Tang
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  8. Xue-Qun Luo
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Correspondence to ** Sun, Yan-Lai Tang or Xue-Qun Luo.

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Tang, WY., Liu, JH., Peng, CJ. et al. Functional Characteristics and Application of Mesenchymal Stem Cells in Systemic Lupus Erythematosus. Arch. Immunol. Ther. Exp. 69, 7 (2021). https://doi.org/10.1007/s00005-021-00603-y

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