70 Result(s)

Article

LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis

The epithelial-mesenchymal transformation (EMT) process of alveolar epithelial cells is recognized as involved in the development of pulmonary fibrosis. Recent evidence has shown that lipopolysaccharide (LPS)-...

**hua Feng, Han Zhong, Shuya Mei, Ri Tang… in Cellular and Molecular Life Sciences (2024)

Article

CPT-11 mitigates autoimmune diseases by suppressing effector T cells without affecting long-term anti-tumor immunity

The incidence of autoimmune diseases has significantly increased over the past 20 years. Excessive host immunoreactions and disordered immunoregulation are at the core of the pathogenesis of autoimmune disease...

Hantian Liang, **nzou Fan, Hao Cheng, **ao Ma, Yutong Sun, Fang Nan… in Cell Death Discovery (2024)

Article

PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia

The crosstalk between astrocytes and microglia plays a pivotal role in neuroinflammation following ischemic stroke, and phenotypic distribution of these cells can change with the progression of ischemic stroke...

Li Peng, Yanyan Ji, Yixin Li, Yan You, Yang Zhou in Cell Communication and Signaling (2024)

Article

Correction: Efficacy of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Animal Model of Female Reproductive Diseases: A Meta-Analysis

Yuanyang Zhou, Qu Li, Shuang You, Huanhuan Jiang… in Stem Cell Reviews and Reports (2024)

Article

Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury

An important pathophysiological process of acute kidney injury (AKI) is mitochondrial fragmentation in renal tubular epithelial cells, which leads to cell death. Pyruvate kinase M2 (PKM2) is an active protein ...

Wenjia **e, Qingyun He, Yan Zhang, **nxin Xu, ** Wen, Hongdi Cao… in Cell Death & Disease (2023)

Article

The complete and fully-phased diploid genome of a male Han Chinese

Since the release of the complete human genome, the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased and well-annotated diploid hu...

Chentao Yang, Yang Zhou, Yanni Song, Dongya Wu, Yan Zeng, Lei Nie… in Cell Research (2023)

Article

Knockdown of Porf-2 restores visual function after optic nerve crush injury

Retinal ganglion cells (RGCs), the sole output neurons in the eyes, are vulnerable to diverse insults in many pathological conditions, which can lead to permanent vision dysfunction. However, the molecular and...

Di Chen, Yi-Yu Sun, Lai-Yang Zhou, Xu Han, Shuo Yang, Fei-Yang Hong… in Cell Death & Disease (2023)

Article

LSM14B controls oocyte mRNA storage and stability to ensure female fertility

Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic development. However, how to regulate mRNA storage and stability in mammalian oogenesis remains elusive. Here we showed...

Li-Ying Shan, Yu Tian, Wen-**ang Liu, Hai-Tao Fan… in Cellular and Molecular Life Sciences (2023)

Article

The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer

This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC pa...

Danyang Zhou, Mei Li, Mohamed Hussein Yasin, Qianyi Lu, Jia Fu… in npj Breast Cancer (2023)

Article

FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells

Female subfertility is an increasing reproductive issue worldwide, which is partially related to abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary physical support and ...

Chen Wang, Hui Sun, John S. Davis, **aojie Wang, Lijun Huo, Nan Sun… in Cell Death & Disease (2023)

Article

Advances in the Mechanistic Study of the Control of Oxidative Stress Injury by Modulating HDAC6 Activity

Oxidative stress is defined as an injury resulting from a disturbance in the dynamic equilibrium of the redox environment due to the overproduction of active/radical oxygen exceeding the antioxidative ability ...

Yuanye Xue, Bing Gan, Yanxing Zhou, Tingyu Wang… in Cell Biochemistry and Biophysics (2023)

Article

Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway

Fibroblast-like synoviocytes (FLS) maintain chronic inflammation leading to joint destruction in rheumatoid arthritis (RA). Fatty acid β-oxidation (FAO) regulates cell function. Here, we aimed to investigate t...

**g Wei, **nxin Huang, **ng Zhang, Guanghong Chen, Cheng Zhang… in Cell Death & Disease (2023)

Article

FcγRIIIA activation-mediated up-regulation of glycolysis alters MDSCs modulation in CD4⁺ T cell subsets of Sjögren syndrome

Our and other researchers’ previous studies found that myeloid-derived suppressor cells (MDSCs) were increased, and these MDSCs, supposed to play immunosuppressive roles, showed significant pro-inflammatory ef...

**g**g Qi, **nyang Zhou, Ziran Bai, Zhimin Lu, **aolu Zhu… in Cell Death & Disease (2023)

Article

Aspirin increases chemosensitivity of colorectal cancer cells and inhibits the expression of toll-like receptor 4

Chemotherapy resistance is an important bottleneck affecting the efficacy of chemotherapy in colon cancer. Therefore, improving the chemotherapy sensitivity of colorectal cancer cells is of great significance ...

Jun Ying, Haiyang Zhou, Zhiguo Wang, Qing You, Junnan Chen… in Cancer Cell International (2023)

Article

Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening

Guangsuo **ng, Zichao Liu, Luyuan Huang, Danyun Zhao… in Cell Death & Differentiation (2022)

Article

Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling

SARS-CoV-2 vaccine booster dose can induce a robust humoral immune response, however, its cellular mechanisms remain elusive. Here, we investigated the durability of antibody responses and single-cell immune p...

**gwen Ai, **gxin Guo, Haocheng Zhang, Yi Zhang, Haochen Yang, Ke Lin… in Cell Discovery (2022)

Article

scMTD: a statistical multidimensional imputation method for single-cell RNA-seq data leveraging transcriptome dynamic information

Single-cell RNA sequencing (scRNA-seq) provides a powerful tool to capture transcriptomes at single-cell resolution. However, dropout events distort the gene expression levels and underlying biological signals...

**g Qi, Qiongyu Sheng, Yang Zhou, Jiao Hua, Shutong **ao, Shuilin ** in Cell & Bioscience (2022)

Article

Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration

Large area skin trauma has always been a great challenge for both patients and clinicians. Exosomes originating from human adipose-derived mesenchymal stem cells (hADSCs) have been a novel promising cell-free ...

Yang Zhou, **ng-Liao Zhang, Shou-Tao Lu, Ning-Yan Zhang… in Stem Cell Research & Therapy (2022)

Article

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not to IC...

Weitong Gao, Xueying Wang, Yang Zhou… in Signal Transduction and Targeted Therapy (2022)

Article

SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation

Increasing research has uncovered the involvement of long noncoding RNAs (lncRNAs) in the progression of multiple cancers including lung adenocarcinoma (LUAD). RT-qPCR and western blot were done to measure RNA...

Yuan Yuan, Danyang Zhou, Feifei Chen, Zhenhua Yang, Wei Gu… in Cell Death & Disease (2022)