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Article
CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex
Previous studies have shown that the C-C motif chemokine ligand 2 (CCL2) is widely expressed in the nervous system and involved in regulating the development of chronic pain and related anxiety-like behaviors,...
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Article
Isobavachalcone’s Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3
Glioblastoma multiforme (GBM) is the most malignant intracranial tumor with high mortality rates and invariably poor prognosis due to its limited clinical treatments. There is an urgent need to develop new the...
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Article
Correction to: 3-Hz Postural Tremor in MSA-C and SCA: Revisiting an Old but Underestimated Cerebellar Sign by Posturography
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Article
Open AccessAstrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Little is known about how the obesogenic environment influences emotional states associated with glial responses and neuronal function. Here, we investigated glial reactivation and neuronal electrophysiologica...
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Article
3-Hz Postural Tremor in MSA-C and SCA: Revisiting an Old but Underestimated Cerebellar Sign by Posturography
The aim of this study is to evaluate the prevalence and electrophysiological features of 3-Hz postural tremor in multiple system atrophy-cerebellar type and spinocerebellar ataxia. A static posturography exami...
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Article
Open AccessBioinformatics analysis of glial inflammatory responses to air pollution
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Article
SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity
The establishment of neuronal connectivity requires precise orchestration of multiple developmental steps, including axon specification, axon guidance, selection of synaptic target sites, and development of sy...
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Article
The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis
Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants and are ubiquitous in the environment and human tissues. Recent evidence has demonstrated that PBDE-induced neurotoxicity is associated w...
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Article
Open AccessSexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of motor and cognitive impairment in children. Clinically, male infants are more vulnerable to ischemic insults and suffer more long-term de...
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Article
Open AccessMet-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection
Infection of rabies virus (RABV) causes central nervous system (CNS) dysfunction and results in high mortality in human and animals. However, it is still unclear whether and how CNS inflammation and immune res...
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Article
Prefrontal Control of Cerebellum-Dependent Associative Motor Learning
Behavioral studies have demonstrated that both medial prefrontal cortex (mPFC) and cerebellum play critical roles in trace eyeblink conditioning. However, little is known regarding the mechanism by which the t...
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White Matter Injury in Global Cerebral Ischemia
In chronic cerebral hypoperfusion due to aging, global cerebral ischemia after cardiac arrest, acute and chronic hypoxia in asymptomatic stroke, and diffuse axonal injury after traumatic brain injury, white ma...