5 Result(s)
-
Article
Open AccessCCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis
Autoimmune uveitis is a leading cause of severe vision loss, and animal models provide unique opportunities for studying its pathogenesis and therapeutic strategies. Here we employ scRNA-seq, RNA-seq and vario...
-
Article
Open AccessImpaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model
Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, de...
-
Article
Open AccessTregs dysfunction aggravates postoperative cognitive impairment in aged mice
Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study...
-
Article
Open AccessLack of neuroinflammation in the HIV-1 transgenic rat: an [18F]-DPA714 PET imaging study
HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PE...
-
Article
Open AccessMolecular profile of cochlear immunity in the resident cells of the organ of Corti
The cochlea is the sensory organ of hearing. In the cochlea, the organ of Corti houses sensory cells that are susceptible to pathological insults. While the organ of Corti lacks immune cells, it does have the ...
