83 Result(s)

Article

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer

Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic. Signals downstream of prolactin...

Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang… in Journal of Experimental & Clinical Cancer … (2024)

Article

Development and validation of an inflammatory biomarkers model to predict gastric cancer prognosis: a multi-center cohort study in China

Inflammatory factors have increasingly become a more cost-effective prognostic indicator for gastric cancer (GC). The goal of this study was to develop a prognostic score system for gastric cancer patients bas...

Shaobo Zhang, Hongxia Xu, Wei Li, Jiuwei Cui, Qingchuan Zhao, Zengqing Guo… in BMC Cancer (2024)

Article

A novel immunogenic cell death-related classification indicates the immune landscape and predicts clinical outcome and treatment response in acute myeloid leukemia

Immunogenic cell death (ICD) is closely related to anti-tumor therapy and regulates the tumor microenvironment (TME). This study aims to explore the molecular characteristics of ICD in acute myeloid leukemia (...

Fangmin Zhong, Shuyang He, Ni Guo, Luyi Shi, Linlin Zhang… in Cancer Cell International (2024)

Article

Outcome in patients with HIV-associated Hodgkin lymphoma treated with chemotherapy using Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine in the combination antiretroviral therapy (cART) era: results of a multicenter study from China

Little is known about the outcome for HIV-associated Hodgkin lymphoma (HIV-HL) as this is less common than HIV-negative lymphoma. Therefore, we performed a multi-center study to analyze the clinical characteri...

Lirong **ao, Chaoyu Wang, Sai Ma, Yifan Wang, Li** Guan… in Infectious Agents and Cancer (2024)

Article

Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression

Natural killer/T cell lymphoma (NKTCL) is a clinically and genetically heterogeneous disease with poor prognosis. Genome sequencing and mutation characterization provides a powerful approach for patient strati...

Zegeng Chen, He Huang, Huangming Hong, Huageng Huang, Huawei Weng, Le Yu… in Genome Medicine (2024)

Article

Characterization of the biological and transcriptomic landscapes of bone marrow-derived mesenchymal stem cells in patients with multiple myeloma

Mesenchymal stem/stromal cells (MSCs) have been acknowledged as the most important stromal cells in the bone marrow (BM) microenvironment for physiologic hematopoiesis and the concomitant hematologic malignanc...

Yu Lu, Chaohui Zheng, Wenxia Zhang, Xuan Liu, Ziwei Zhou… in Cancer Cell International (2024)

Article

LncRNA WFDC21P interacts with SEC63 to promote gastric cancer malignant behaviors by regulating calcium homeostasis signaling pathway

Gastric cancer is currently estimated to be the fifth leading common cancer in the world, and responsible for about one million new cases and an estimated 769,000 cancer-related deaths each year. WFDC21P is lo...

**yao Dong, Yongqiang Lv, Debin Meng, Ruyi Shi, Feng Li… in Cancer Cell International (2024)

Article

Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family

Genetic susceptibility to familial colorectal cancer (CRC), including for individuals classified as Familial Colorectal Cancer Type X (FCCTX), remains poorly understood. We describe a multi-generation CRC-affe...

James M. Chan, Mark Clendenning, Sharelle Joseland, Peter Georgeson… in Familial Cancer (2024)

Article

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis

Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some of NPC patients have bone metastases at the time of initial diagnosis. Bone metastasis can cause pathologi...

Kaifan Yang, Yanjun Hu, Yuanyuan Feng… in Journal of Experimental & Clinical Cancer … (2024)

Article

EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL

Hepatocellular Carcinoma (HCC) is a matter of great global public health importance; however, its current therapeutic effectiveness is deemed inadequate, and the range of therapeutic targets is limited. The ai...

Mingang Pan, Muyu Luo, Lele Liu… in Journal of Experimental & Clinical Cancer … (2024)

Article

RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPKα2 to activate oxidative phosphorylation and fatty acid oxidation

More than 90% of the mortality of triple-negative breast cancer (TNBC) patients is attributed to cancer metastasis with organotropism. The lung is a frequent site of TNBC metastasis. However, the precise molec...

Shaojie Cheng, Xueying Wan, Li** Yang… in Journal of Experimental & Clinical Cancer … (2023)

Article

CT-based deep learning model: a novel approach to the preoperative staging in patients with peritoneal metastasis

Peritoneal metastasis (PM) is a frequent manifestation of advanced abdominal malignancies. Accurately assessing the extent of PM before surgery is essential for patients to receive optimal treatment. Therefore...

Jipeng Wang, Yuannan Hu, Hao **ong, Tiantian Song… in Clinical & Experimental Metastasis (2023)

Article

TSTA3 overexpression promotes malignant characteristics in LUSC by regulating LAMP2-mediated autophagy and tumor microenvironment

TSTA3 gene encoding GDP-l-fucose synthase has recently been proved to be closely related to the prognosis of patients with various tumors. However, its role in lung cancer is still unclear. The purpose of this st...

Yanlin Guo, Yanlong Hao, Liuyi Shen, Yu Du, **aohui Wang… in Cancer Cell International (2023)

Article

Eleven metabolism‑related genes composed of Stard5 predict prognosis and contribute to EMT phenotype in HCC

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with a high mortality and poor survival rate. Abnormal tumor metabolism is considered a hallmark of HCC and is a potential therapeuti...

Dong** Li, **ahui Lin, Jiale Li, **nyi Liu, Feng Zhang… in Cancer Cell International (2023)

Article

Cytokine release syndrome was an independent risk factor associated with hypoalbuminemia for patients with relapsed/refractory hematological malignancies after CAR-T cell therapy

This study aims to assess the nutritional status of patients during the different phases of the Chimeric Antigen Receptor (CAR)-T cell therapy and to identify prominent risk factors of hypoalbuminemia in patie...

Shuyi Ding, Rongrong Chen, Linqin Wang, Cheng Zu, **aoyu Zhou, Jianli Zhang… in BMC Cancer (2023)

Article

Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment

Tumor cell-induced platelet aggregation (TCIPA) is not only a recognized mechanism for paraneoplastic thrombocytosis but also a potential breakthrough alternative for a low response to immune checkpoint inhibi...

Yuyi Chen, Jie Zhou, Zishen Liu, Tongtong Wu… in Journal of Experimental & Clinical Cancer … (2023)

Article

Development and validation a radiomics nomogram for predicting thymidylate synthase status in hepatocellular carcinoma based on Gd-DTPA contrast enhanced MRI

The purpose of this study was to develop and validate a radiomics nomogram for predicting thymidylate synthase (TYMS) status in hepatocellular carcinoma (HCC) by using Gd-DTPA contrast enhanced MRI.

Zongren Ding, Yijun Wu, Guoxu Fang, Zhaowang Lin, Kongying Lin, Jun Fu… in BMC Cancer (2023)

Article

Integrative analysis of the prognostic value and immune microenvironment of mitophagy-related signature for multiple myeloma

Multiple myeloma (MM) is a fatal malignant tumor in hematology. Mitophagy plays vital roles in the pathogenesis and drug sensitivity of MM.

Yachun Jia, Rui Liu, Luyi Shi, Yuandong Feng, Linlin Zhang, Ni Guo, Aili He… in BMC Cancer (2023)

Article

Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress

Gemcitabine (GEM)-based chemotherapy is the first-line option for pancreatic ductal adenocarcinoma (PDAC). However, the development of drug resistance limits its efficacy, and the specific mechanisms remain la...

Chunhua She, Chao Wu, Weihua Guo… in Journal of Experimental & Clinical Cancer … (2023)

Article

Retraction Note: N6-methyladenosine induced mir-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1

Hongsheng Wang, Qianqian Deng, Ziyan Lv, Yuyi Ling, Xue Hou… in Molecular Cancer (2023)