56 Result(s)

Article

Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells

Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such ...

Guangsheng Zhu, Yanan Wang, Yingjie Wang, Hua Huang, Boshi Li… in Cell Death & Disease (2024)

Article

Correction: CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer

Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li… in Cell Death & Disease (2024)

Article

Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy

Transcription-coupled nucleotide excision repair (TC-NER) is an important genome maintenance system that preferentially removes DNA lesions on the transcribed strand of actively transcribed genes, including no...

Ya** Huang, Liya Gu, Guo-Min Li in Cell Discovery (2023)

Article

CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer

Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling. Inhibiting effects of AR may activate neuroendocrine differentiation and lineage plasticity pathways, thereby ...

Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li… in Cell Death & Disease (2023)

Article

Interleukin-18-primed human umbilical cord-mesenchymal stem cells achieve superior therapeutic efficacy for severe viral pneumonia via enhancing T-cell immunosuppression

Coronavirus disease 2019 (COVID-19) treatments are still urgently needed for critically and severely ill patients. Human umbilical cord-mesenchymal stem cells (hUC-MSCs) infusion has therapeutic benefits in CO...

Yan Liao, Zeqin Fu, Yinfu Huang, Shiduo Wu, Zhen Wang, Shaotang Ye… in Cell Death & Disease (2023)

Article

Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes

Ischemic diseases represent a major global health care burden. Angiogenesis is critical in recovery of blood flow and repair of injured tissue in ischemic diseases. Ten–eleven translocation protein 2 (TET2), a...

Yefei Shi, Bo Li, **nru Huang, Wenxin Kou, Ming Zhai, Yanxi Zeng… in Cell & Bioscience (2023)

Article

Loss of function of CMPK2 causes mitochondria deficiency and brain calcification

Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulatio...

Miao Zhao, Hui-Zhen Su, Yi-Heng Zeng, Yuan Sun, **n-**n Guo, Yun-Lu Li… in Cell Discovery (2022)

Article

The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1

Long noncoding RNAs (lncRNAs) are usually 5′ capped and 3′ polyadenylated, similar to most typical mRNAs. However, recent studies revealed a type of snoRNA-related lncRNA with unique structures, leading to que...

Wei Huang, Yu-Meng Sun, Qi Pan, Ke Fang, **ao-Tong Chen, Zhan-Cheng Zeng… in Cell Discovery (2022)

Article

E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING

Ring-finger protein 5 (RNF5) is an E3 ubiquitin ligase which is expressed in a variety of human tissues. RNF5 is involved in the regulation of endoplasmic reticulum stress, inflammation, and innate immunity an...

Lu-Lu Yang, Wen-Chang **ao, Huan Li, Zheng-Yang Hao, Gui-Zhi Liu… in Cell Death & Disease (2022)

Article

Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding

Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level I...

**aohua Tang, Rui Sun, Weigang Ge, Tingting Mao, Liujia Qian… in Cell Discovery (2022)

Article

Retinoic acid inhibits the angiogenesis of human embryonic stem cell-derived endothelial cells by activating FBP1-mediated gluconeogenesis

Endothelial cells are located in the inner lumen of blood and lymphatic vessels and exhibit the capacity to form new vessel branches from existing vessels through a process called angiogenesis. This process is...

Zhuangzhuang Yang, Miao Yu, Xuechun Li, Yuanyuan Tu… in Stem Cell Research & Therapy (2022)

Article

The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy

Transient receptor potential melastatin 8 (TRPM8) functions as a Ca²⁺-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in c...

Yuan Huang, Shi Li, Qinfeng Liu, Zhijie Wang, Shunyao Li, Lei Liu… in Cell Death & Disease (2022)

Article

Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex

Nuclear pore complexes (NPCs) mediate bidirectional nucleocytoplasmic transport of substances in eukaryotic cells. However, the accurate molecular arrangement of NPCs remains enigmatic owing to their huge size...

Zongqiang Li, Shuaijiabin Chen, Liang Zhao, Guoqiang Huang, **ong Pi… in Cell Research (2022)

Article

HIF-1α-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction

Myocardial infarction (MI) is a fatal heart disease that affects millions of lives worldwide each year. This study investigated the roles of HIF-1α/lncRNA-TUG1 in mitochondrial dysfunction and pyroptosis in MI...

Yong-Wang Wang, Hong-Zhi Dong, Yong-**ng Tan, Xu Bao, Ying-Man Su… in Cell Death Discovery (2022)

Article

Retraction Note: Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro

** Xu, Hong-li He, Shu-ling Hu, Ji-bin Han… in Stem Cell Research & Therapy (2022)

Article

USP12 promotes CD4⁺ T cell responses through deubiquitinating and stabilizing BCL10

Deubiquitinases (DUBs) regulate diverse biological processes and represent a novel class of drug targets. However, the biological function of only a small fraction of DUBs, especially in adaptive immune respon...

Yuling Fu, Peng Wang, **g**g Zhao, Yunke Tan, Junli Sheng… in Cell Death & Differentiation (2021)