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Article
Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study
Membranous nephropathy (MN) is a rare complication that can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT). MN patients may develop nephrotic syndrome or even kidney failure, which ...
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Article
Open AccessExperiences of family caregivers taking care getting lost of persons with dementia: a qualitative study
Getting lost with family members who have dementia is a significant source of stress for family caregivers. In Taiwan, family caregivers develop strategies to deal with dementia persons who may get lost. This ...
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Article
Open AccessCounterion docking: a general approach to reducing energetic disorder in doped polymeric semiconductors
Molecular do** plays an important role in controlling the carrier concentration of organic semiconductors. However, the introduction of dopant counterions often results in increased energetic disorder and tr...
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Article
Association of sleep fragmentation with general and abdominal obesity: a population-based longitudinal study
To evaluate the causal relationship between sleep fragmentation (SF) parameters with general and abdominal obesity in free-living conditions.
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Article
Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes
The High Altitude Detection of Astronomical Radiation (HADAR) experiment, which was constructed in Tibet, China, combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity ...
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Article
Proteomics Sequencing Reveals the Role of TGF-β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride
The underlying mechanism of fluorosis has not been fully elucidated. The purpose of this study was to explore the mechanism of fluorosis induced by sodium fluoride (NaF) using proteomics. Six offspring rats ex...
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Article
Open AccessA new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers
Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated ...
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Article
Open AccessThe impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial
This study examines the oral health benefits of heat-killed Lacticaseibacillus paracasei GMNL-143, particularly its potential in oral microbiota alterations and gingivitis improvement.
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Open AccessPlanning, implementing, and evaluating Hepatitis C virus elimination via collaborative community-based care cascade: age–period–cohort model for estimating demand from antecedent anti-HCV survey
Estimating the demand for HCV care cascade plays an important role in planning, monitoring, and assessing the performance of introducing a new community-based hepatitis C virus (HCV) elimination program but su...
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Article
Open AccessLong-term complications and outcomes of augmentation cystoplasty in children with neurogenic bladder
Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed. The present study aimed to determine the risks of metabolic c...
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Article
Open AccessPick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell
The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applica...
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Article
Open AccessCamrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial
The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Patients with N3 nasopharyngeal carcinoma have a high risk of distant m...
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Article
Swelling inhibition and infiltration promotion mechanism of polyethyleneimine
In order to solve landslides and slow infiltration rate in in-situ leaching process of weathered crust elution-deposited rare earth ore (WCE-DREO), the swelling inhibition performance and mechanism of polyethy...
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Article
Open AccessSerum IGFBP-1 as a promising diagnostic and prognostic biomarker for colorectal cancer
Our previous study showed that levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) has potential diagnostic value for early-stage upper gastrointestinal cancers. This study aimed to as...
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Article
Open AccessSH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation
Platinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing chemotherapy f...
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Article
Open AccessIncreased cysteinyl-tRNA synthetase drives neuroinflammation in Alzheimer’s disease
Microglia-mediated neuroinflammation in Alzheimer’s disease (AD) is not only a response to pathophysiological events, but also plays a causative role in neurodegeneration. Cytoplasmic cysteinyl-tRNA synthetase...
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Article
Health-related quality of life in Chinese SLE patients: evidence from 1568 SLE patients and 2610 healthy controls
To investigate the effects of systemic lupus erythematosus (SLE) on health-related quality of life (HRQOL), the relationship between disease activity and HRQOL, and potential factors affecting HRQOL in Chinese...
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Article
Open AccessUbiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers
Killer meiotic drivers (KMDs) skew allele transmission in their favor by killing meiotic progeny not inheriting the driver allele. Despite their widespread presence in eukaryotes, the molecular mechanisms behi...
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Article
Open AccessActivation of the glutamatergic cingulate cortical-cortical connection facilitates pain in adult mice
The brain consists of the left and right cerebral hemispheres and both are connected by callosal projections. Less is known about the basic mechanism of this cortical-cortical connection and its functional imp...
