108 Result(s)

Article

Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System

Serotonin (5-HT₃) receptor antagonists are promising agents for treatment of neuropathic pain. However, insufficient drug exposure at the central nervous system (CNS) might result in lack of efficacy. The goal of...

Manting Chiang, Hyunmoon Back, Jong Bong Lee, Sarah Oh… in Pharmaceutical Research (2024)

Article

Idebenone Antagonizes P53-Mediated Neuronal Oxidative Stress Injury by Regulating CD38-SIRT3 Protein Level

Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD...

Hao Xu, Ying Guo, **ao-Jun Liu, Ying Liu, Shi Yin, Qi-Ying Bao… in Neurochemical Research (2024)

Article

The Mutual Regulatory Role of Ferroptosis and Immunotherapy in Anti-tumor Therapy

Ferroptosis is a form of cell death that is triggered by the presence of ferrous ions and is characterized by lipid peroxidation induced by these ions. The mechanism exhibits distinct morphological characteris...

Zhiguo Mao, Yilong Hu, Yinan Zhao, **aolei Zhang, Lin Guo, **aoran Wang… in Apoptosis (2024)

Article

Generation of realistic virtual adult populations using a model-based copula approach

Incorporating realistic sets of patient-associated covariates, i.e., virtual populations, in pharmacometric simulation workflows is essential to obtain realistic model predictions. Current covariate simulation...

Yuchen Guo, Tingjie Guo… in Journal of Pharmacokinetics and Pharmacody… (2024)

Article

Prevalence and genetic basis of Mycobacterium tuberculosis resistance to pretomanid in China

Pretomanid is a key component of new regimens for the treatment of drug-resistant tuberculosis (TB) which are being rolled out globally. However, there is limited information on the prevalence of pre-existing ...

Bing Zhao, Huiwen Zheng, Juliano Timm… in Annals of Clinical Microbiology and Antimi… (2024)

Article

MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1

MARCH5 is a ring-finger E3 ubiquitin ligase located in the outer membrane of mitochondria. A previous study has reported that MARCH5 was up-regulated and contributed to the migration and invasion of OC cells b...

Ying Xu, Shuhua Zhao, Yujie Shen, Yuanfeng Li, Yinghui Dang, Fenfen Guo… in Apoptosis (2024)

Article

Cuproptosis-Related Gene FDX1 Suppresses the Growth and Progression of Colorectal Cancer by Retarding EMT Progress

Colorectal cancer (CRC) is a usual cancer and a kind of lethiferous cancer. Cuproptosis-related gene ferredoxin 1 (FDX1) has been discovered to act as a suppressor, thereby suppressing some cancers’ progressio...

Chao Wang, **g**g Guo, Yun Zhang, Shusheng Zhou, Bing Jiang in Biochemical Genetics (2024)

Article

Correction: Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons

Shiji Liao, Guirong Qiu, Yan** Hu, Bohong Guo, Yuqin Qiu in AAPS PharmSciTech (2024)

Article

Identification and Functional Mechanism Verification of Novel MicroRNAs Associated with the Fibrosis Progression in Chronic Kidney Disease

Chronic kidney disease (CKD) is a serious threat to human health worldwide, and its incidence is increasing annually. A growing amount of information is emerging about the role of micoRNAs (miRNAs) in the reg...

Kaiying He, **aochun Zhou, **g Zhao, Hongxuan Du, Juan Guo… in Biochemical Genetics (2024)

Article

Cuproptosis-Associated lncRNA Gene Signature Establishes New Prognostic Profile and Predicts Immunotherapy Response in Endometrial Carcinoma

Uterine corpus endometrial carcinoma (UCEC), a prevalent kind of cancerous tumor in female reproductive system that has a dismal prognosis in women worldwide. Given the very limited studies of cuproptosis-rela...

**-Ya Jiang, **g-**g Hu, Rui Wang, Wei-Yu Zhang, Qin-Qin **… in Biochemical Genetics (2023)

Article

Transcranial alternating current stimulation ameliorates emotional attention through neural oscillations modulation

Numerous clinical reports have suggested that psychopathy like schizophrenia, anxiety and depression is accompanied by early attentional abnormalities in emotional processing. Recently, the efficacy of transcr...

Shuang Liu, Yuchen He, Dongyue Guo, **aoya Liu, **nyu Hao… in Cognitive Neurodynamics (2023)

Article

Identification of Bone Metastatic and Prognostic Alternative Splicing Signatures in Prostate Adenocarcinoma

As the most common nonepithelial malignancy, prostate adenocarcinoma (PRAD) is the fifth chief cause of cancer mortality in men. Distant metastasis often occurs in advanced PRAD and most patients are dying fro...

Jiwen Zhu, Jiayao Zhang, Peng Hu, Mingxiang Fan, Dianwen Song… in Biochemical Genetics (2023)

Article

Wearable Neuromuscular Electrical Stimulation on Quadriceps Muscle Can Increase Venous Flow

Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) may increase venous blood flow to reduce the risk of venous thromboembolism. This study assessed whether Q-NMES pants could increase peak venou...

Johanna Flodin, Philip Wallenius, Li Guo… in Annals of Biomedical Engineering (2023)

Article

Drug Dissolution in Oral Drug Absorption: Workshop Report

The in-person workshop “Drug Dissolution in Oral Drug Absorption” was held on May 23–24, 2023, in Baltimore, MD, USA. The workshop was organized into lectures and breakout sessions. Three common topics that we...

Kimberly Raines, Payal Agarwal, Patrick Augustijns, Alaadin Alayoubi… in The AAPS Journal (2023)

Article

Correction: Angiotensin-(1–9) prevents Angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway

Chun-ling Guo, Hui-min Liu, Bao Li, Zhao-yang Lu in Apoptosis (2023)

Article

The Study of Overexpression of Peroxiredoxin-2 Reduces MPP⁺-Induced Toxicity in the Cell Model of Parkinson’s Disease

Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by dopaminergic neuron loss, which is related to excessive reactive oxygen species (ROS) accumulation. Endogenous peroxiredoxin-2 ...

Menghao Liu, Shuqian Zuo, **ng Guo, Junyu Peng, … in Neurochemical Research (2023)

Article

Abundant diversity of accessory genetic elements and associated antimicrobial resistance genes in pseudomonas aeruginosa isolates from a single Chinese hospital

Pseudomonas aeruginosa has intrinsic antibiotic resistance and the strong ability to acquire additional resistance genes. However, a limited number of investigations provide detailed modular structure dissection ...

**aofei Mu, **nyue Li, Zhe Yin, Ying **g… in Annals of Clinical Microbiology and Antimi… (2023)

Article

Correction: Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets

Yasuhiro Tsume, Lee Ashworth, Marival Bermejo, Joan Cheng… in The AAPS Journal (2023)

Article

Correction to: Bacomics: a comprehensive cross area originating in the studies of various brain–apparatus conversations

Dezhong Yao, Yangsong Zhang, Tiejun Liu, Peng Xu, Diankun Gong… in Cognitive Neurodynamics (2023)

Article

Potential Use of Artificial Intelligence in Infectious Disease: Take ChatGPT as an Example

Over the past month, a new AI model called Chatbot Generative Pre-trained Transformer (ChatGPT), has received enormous attention in the media and scientific communities due to its ability to process and respon...

Kunming Cheng, Zhiyong Li, Yongbin He, Qiang Guo… in Annals of Biomedical Engineering (2023)