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Open AccessStandardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
There is a significant demand for intermediate-scale bioreactors in academic and industrial institutions to produce cells for various applications in drug screening and/or cell therapy. However, the applicatio...
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Article
Open AccessPolar microalgae extracts protect human HaCaT keratinocytes from damaging stimuli and ameliorate psoriatic skin inflammation in mice
Polar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our first line of defense against external threats, polar microalgae extracts may possess res...
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Article
Open AccessSARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype
Since the emergence of the Omicron variants at the end of 2021, they quickly became the dominant variants globally. The Omicron variants may be more easily transmitted compared to the earlier Wuhan and the oth...
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Article
Surface-Modifying Effect of Zwitterionic Polyurethane Oligomers Complexed with Metal Ions on Blood Compatibility
To prevent unsolved problems of medical devices, we hypothesized that combinatorial effects of zwitterionic functional group and anti-bacterial metal ions can reduce effectively the thrombosis and bacterial in...
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Article
Open AccessDAF-2c signaling promotes taste avoidance after starvation in Caenorhabditis elegans by controlling distinct phospholipase C isozymes
Previously, we reported that DAF-2c, an axonal insulin receptor isoform in Caenorhabditis elegans, acts in the ASER gustatory neuron to regulate taste avoidance learning, a process in which worms learn to avoid s...
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Article
Open AccessSmall intestinal immune-environmental changes induced by oral tolerance inhibit experimental atopic dermatitis
Atopic dermatitis is a chronic skin inflammatory disease mediated by Th2-type immune responses. Although intestinal immune responses have been shown to play a critical role in the development or prevention of ...
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Article
Open AccessNeuron ID dataset facilitates neuronal annotation for whole-brain activity imaging of C. elegans
Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identi...
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Article
Treatment with granulocyte colony-stimulating factor aggravates thrombocytopenia in irradiated mice
Ionizing radiation can damage the hematopoietic system, and treatment with cytokines, including granulocytecolony-stimulating factor (G-CSF), is used to enhance hematopoietic recovery. In the present study, mi...
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Article
Expression of DcHsp17.7, a small heat shock protein gene in carrot (Daucus carota L.)
We examined the expression pattern of the small heat shock protein (sHSP) gene, DcHsp17.7, under various conditions. In non-stressed leaf tissue, DcHsp17.7 was absent or present at very low levels; however, expos...
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Article
The hrpN gene of Erwinia amylovora stimulates tobacco growth and enhances resistance to Botrytis cinerea
Erwinia amylovora is a member of the harpin proteins that induces pathogen resistance and hypersensitive cell death in plants. To obtain tobacco plants displaying a hypersensitive respons...