105 Result(s)

Article

Hairy cell leukemia variant and WHO classification correspondence Re: 5^th edition WHO classification haematolymphoid tumors: lymphoid neoplasms

Michael Grever, Leslie Andritsos, Mirela Anghelina, Evgeny Arons… in Leukemia (2024)

Article

Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation

DEAD box helicase 41 (DDX41) mutations are the most prevalent predisposition to familial myelodysplastic syndrome (MDS). However, the precise roles of these variants in the pathogenesis of MDS have yet to be e...

Won Chan Hwang, Kibeom Park, Silvia Park, Na Young Cheon, Ja Yil Lee… in Leukemia (2024)

Article

Prediction of TKI response in EGFR-mutant lung cancer patients-derived organoids using malignant pleural effusion

Patient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs are ideal models for precision oncologists. However, their practical application in guiding timely clinical decision...

Sang-Hyun Lee, Kyuhwan Kim, Eunyoung Lee, Kyungmin Lee… in npj Precision Oncology (2024)

Article

Long-term oncologic outcomes of unselected triple-negative breast cancer patients according to BRCA1/2 mutations

Triple-negative breast cancer (TNBC) patients are more likely to have BRCA1/2 mutations, with a prevalence rate of about 10–20%. Although several studies have analyzed the oncologic outcomes between BRCA1/2 carri...

Woong Ki Park, Soo Yeon Chung, You ** Jung, Changhee Ha… in npj Precision Oncology (2024)

Article

ELAVL2 loss promotes aggressive mesenchymal transition in glioblastoma

Glioblastoma (GBM), the most lethal primary brain cancer, exhibits intratumoral heterogeneity and molecular plasticity, posing challenges for effective treatment. Despite this, the regulatory mechanisms underl...

Yona Kim, Ji Hyeon You, Yeonjoo Ryu, Gyuri Park, Urim Lee… in npj Precision Oncology (2024)

Article

Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET–mutant thyroid cancer

Genetic alternation of REarranged during Transfection (RET) that leads to constitutive RET activation is a crucial etiological factor for thyroid cancer. RET is known to regulate mitochondrial processes, although...

Wen**g Chen, Sophie Dream, Pui-Yin Leung, Pui-Kei Wu… in npj Precision Oncology (2024)

Article

Immunological subty** of salivary gland cancer identifies histological origin-specific tumor immune microenvironment

Gene expression analysis enhances proper cancer subty**, a better understanding of the molecular characteristics of cancer, and strategies for precision medicine. However, salivary gland cancer (SGC) subtypi...

Jiyun Hong, Eunwoo Choi, Dahee Kim, Mi-Kyoung Seo, Hyundeok Kang… in npj Precision Oncology (2024)

Article

Artificial intelligence-powered spatial analysis of tumor-infiltrating lymphocytes for prediction of prognosis in resected colon cancer

Tumor-infiltrating lymphocytes (TIL) have been suggested as an important prognostic marker in colorectal cancer, but assessment usually requires additional tissue processing and interpretational efforts. The a...

Yoojoo Lim, Songji Choi, Hyeon Jeong Oh, Chanyoung Kim… in npj Precision Oncology (2023)

Article

Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases

Melanoma brain metastases (MBM) are clinically challenging to treat and exhibit variable responses to immune checkpoint therapies. Prior research suggests that MBM exhibit poor tumor immune responses and are e...

Gino K. In, Jennifer R. Ribeiro, Jun Yin, Joanne **u… in npj Precision Oncology (2023)

Article

Perspectives on acute myeloid leukemia diagnosis: a comparative analysis of the latest World Health Organization and the International Consensus Classifications

** Jung, Daehun Kwag, Yonggoo Kim, Jong-Mi Lee, Ari Ahn, Hoon Seok Kim… in Leukemia (2023)

Article

ML-based sequential analysis to assist selection between VMP and RD for newly diagnosed multiple myeloma

Optimal first-line treatment that enables deeper and longer remission is crucially important for newly diagnosed multiple myeloma (NDMM). In this study, we developed the machine learning (ML) models predicting...

Sung-Soo Park, Jong Cheol Lee, Ja Min Byun, Gyucheol Choi… in npj Precision Oncology (2023)

Article

Dramatic, durable response to therapy in gBRCA2-mutated pancreas neuroendocrine carcinoma: opportunity and challenge

Poorly differentiated pancreatic neuroendocrine tumors (PDNEC), are a subtype of pancreatic cancer encompassing both small cell and large cell neuroendocrine carcinoma subtypes, and are characterized as distin...

Fergus Keane, Raazi Bajwa, Pier Selenica, Wungki Park… in npj Precision Oncology (2023)

Article

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

The biosynthesis of host lipids and/or lipid droplets (LDs) has been studied extensively as a putative therapeutic target in diverse viral infections. However, directly targeting the LD lipolytic catabolism in...

Yeong-Bin Baek, Hyung-Jun Kwon, Muhammad Sharif… in Signal Transduction and Targeted Therapy (2022)