290 Result(s)
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Article
Oleamide–PDMS copolymer for coating urinary catheters with anti-adhesive and anti-biofilm properties
Biofilm formation on biomedical devices is a prevalent problem that can result in several complications and is responsible for over 80% of all clinical infections. Successful treatment of biofilms requires a 1...
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Article
Ethyl acetate layer of a methanol extract from Aquilaria crassna promotes oxidative stress-mediated apoptosis in non-small-cell lung cancer cells
Chemotherapy is the cornerstone for treating most types of cancer; however, it has a variety of side effects and tumor cells can become resistant to its effects. To overcome these obstacles, natural products h...
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Article
Fucoidan ameliorates amyloid-β 42 oligomer-induced neuronal apoptosis by activating the PI3K/Akt signaling pathway and MAPK cascades in human neuroblastoma SH-SY5Y cells
Fucoidan, a polysaccharide derived from brown seaweed, has multiple biological properties, including antioxidant, antitumor, anticoagulant, and anti-inflammatory effects. However, there are few reports on thei...
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Evaluation of the antinociceptive effect and standardization of Platycladus orientalis (L.) Franco extract
Platycladus orientalis (L.) Franco (PO) has been used in Oriental medicine to treat rheumatism and diarrhea; however, its antinociceptive effects remain unclear.
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Article
Unveiling the toxicological impact of yeast vacuoles in Daphnia
The spread of introduced species necessitates effective management strategies. However, the current methods have proven ineffective, thus calling for alternative solutions.
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Cytotoxicity-reducing and anti-inflammatory effects of a natural herb mixture extract
Natural herb mixture extracts have been used in traditional medicine in many countries for several years and are currently widely used as alternative medicines, even in Western countries. These extracts have l...
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Article
Cucurbitacin-I exhibits anticancer activity by inducing apoptosis in SKOV3 human ovarian cancer cells
Cucurbitacin-I is a natural cell-permeable triterpenoid compound isolated from Cucurbitaceae and Cruciferae. The pharmacological activity of cucurbitacin-I in human ovarian cancer has been rarely reported.
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Article
Cobrotoxin, a single peptide from snake venom, ameliorates atopic dermatitis via suppression of MK2 modulated by IgE and IL-33
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease, causing significant impairment in daily life. It typically results from the compromised skin barriers and induces the Th2-dominant immun...
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Article
Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection
Neurodegenerative diseases show various phenotypes of molecular and cellular malfunction including mitochondrial dysfunction and neuroinflammation. These molecular dynamics are based on the epigenetic regulati...
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Article
New insight of exercise on dementia; combinatory effects of physical and cognitive exercise
Dementia is a progressive neurological disorder which is clinically characterized by memory loss, behavioral symptoms, and loss of ability to live a normal life. Dementia patients may have to cope with permane...
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Article
Tolylfluanid induces developmental toxicity via liver dysfunction in zebrafish embryos
Tolylfluanid is a phenylsulfamide fungicide used to mitigate enormous losses in agriculture and coastal industries. Previous studies have reported that exposure to tolylfluanid causes metabolic dysfunction, su...
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Article
Prediction of herb–drug interaction between hyperforin and sedative hypnotics (zolpidem, alprazolam, and midazolam) using physiologically-based pharmacokinetic modeling
This study investigates the interactions between various doses of hyperforin, a key compound in St. John’s Wort, and sedative hypnotics such as zolpidem, alprazolam, and midazolam. Since St John’s Wort is know...
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Article
Open AccessAnti-melanogenic effect of Moju through inhibition of tyrosinase activity
Moju is a traditional rice beverage local to Jeonju with an alcohol content of 1–2%. Moju is made by boiling makgeolli with several kinds of medicinal herbs, such as ginger, jujube and cinnamon. The raw materi...
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Article
Scallop-derived plasmalogen attenuates amyloid beta-induced inflammation and apoptosis in SH-SY5Y cells
With an increase in the world’s aging population, candidate substances for the management of neurodegenerative diseases, including Alzheimer’s disease (AD), have received considerable attention. Amyloid beta (...
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Low-dose-rate gamma radiation aggravates titanium dioxide nanoparticle-induced lung injury in mice
Radiation damage and the cellular response has been studied in various direction, however, the synergic effects of radiation damage with environmental pollution on cells or tissues remained poorly understood. ...
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Establishment of a small-cell lung cancer (SCLC) mouse model using enhanced cancer stem-cell-functioning 3D SCLC spheroids
Despite its low incidence rate, small-cell lung cancer (SCLC), which accounts for approximately 10%–15% of all lung cancers, is concerningly characterized by its rapid progression, strong metastatic potential,...
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Olaparib synergically exacerbates the radiation-induced intestinal apoptosis in mice
Olaparib, a poly [ADP-ribose] polymerase (PARP) inhibitor, is used in cancer treatment and in other diseases and achieves local cancer control in combination with radiotherapy.
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Genotoxicity evaluation of collagen peptide derived from skate (Raja kenojei) skin: In vitro and in vivo studies
The medicinal properties and benefits of collagen peptides (CPs) are widely recognized and utilized. However, the potential genotoxicity of CPs remains elusive.
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Article
Adipogenic effects of Ostreae Testa water extract on white adipocytes
Obesity and its associated diseases have become a concerning health issue not only in the middle-aged population but also in young children due to changes in lifestyle and food intake. However, the existing ph...
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Article
Identification of allergens in Acorus gramineus using protein analysis
Food allergy reactions have been increasing over the past 5 years. In addition, we are always exposed to the risk of allergies because the herbal medicines we mainly use are used in these foods.
