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Reference Work Entry In depth
Benefits and Pitfalls of Tumor Vessel Normalization
Tumor vasculature has been intensively studied not only to understand its role in tumor progression and metastasis but also to discover regulatory pro- and anti-angiogenic molecules and cells. Until now, numer...
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Reference Work Entry In depth
Tregs
Regulatory T cells (Tregs) are a subtype of T cells with immune suppressive function and play a key role in immune self-tolerance. Its immune inhibitory function has been implicated as the important mechanism ...
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Reference Work Entry In depth
Immunohistochemistry as Biomarker Platform in Endometrial Cancer
Endometrial cancer is the most common malignancy of the female genital tract in Western countries, and its incidence is rapidly increasing in Asia. The standard treatment for women with endometrial cancer is s...
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Living Reference Work Entry In depth
Immunohistochemistry as Biomarker Platform in Endometrial Cancer
Endometrial cancer is the most common malignancy of the female genital tract in Western countries, and its incidence is rapidly increasing in Asia. The standard treatment for women with endometrial cancer is s...
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Protocol
The Ex Vivo Use of Keratinocytes from Adult Mice to Define Stem Cell Activities in Cancer Research
Primary keratinocytes are harvested from the dorsal skin of 7-week-old mice. Euthanized mice are clipped and cleaned with serial washes in povidone iodine and ethanol solutions. The dorsal skin is removed and ...
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Living Reference Work Entry In depth
Tregs
Regulatory T cells (Tregs) are a subtype of T cells with immune suppressive function and play a key role in immune self-tolerance. Its immune inhibitory function has been implicated as the important mechanism ...
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Chapter
Ceramide Synthases: Reexamining Longevity
The ceramide synthase (CerS) enzymes catalyze the formation of (dihydro) ceramide, and thereby provide critical complexity to all sphingolipids (SLs) with respect to their acyl chain length. This review summar...
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Protocol
Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting
Currently, the principal chemistries for the preparation of antibody–drug conjugates (ADC) target either lysines or cysteines for coupling cytotoxic drugs for delivery to target cells expressing tumor-specific...
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Chapter
Acetylcholinesterase as a Pharmacological Target in Cancer Research
Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. This catalytic property of acetylcholinesterase made it focus of intense research for much of the past cen...
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Chapter and Conference Paper
Recommended Vitamin C Intake: From Molecular Mechanisms to Clinical Application
The current recommended dietary allowance in the United States (U.S. RDA) for vitamin C (ascorbate) is 60 mg daily [1, 2]. Similar or lower values are used in other countries throughout the world except France...