1,097 Result(s)
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**su Park
Biomedicine
Biomedicine, general
Cancer Research
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Article
The Malignancy of Cancer at Different Ages: A Histological Study
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Article
Differential permeability of lymphatic and blood vessels in determining the route of metastasis as demonstrated by indirect lymphography
Indirect mammo-lymphography with serial radiograms was made on rats bearing three established rat mammary carcinomas (SMT-2A, TMT-50, MT-W9B), with the water-soluble contrast medium, Iotasul. In the lymphogeno...
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Article
The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse
The gene encoding the granulocyte macrophage colony stimulating factor receptor α subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report ...
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The epidemiology of AIDS-associated non-Hodgkin's lymphoma in the World Health Organization European Region
This paper describes the epidemiology of AIDS-associated non-Hodgkin's lymphoma (NHL) in the World Health Organization (WHO) European Region. Data, collected by the WHO Collaborating Centre on AIDS in Paris, F...
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Article
Interleukin 2 therapy in cancer: identification of responders
C-reactive protein (CRP) levels in serum were measured in fifteen patients with metastatic colorectal carcinoma, prior to and during treatment with a continuous intravenous infusion of rIL.2. Patients were sub...
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Article
The Wilms tumour gene WT1 is expressed in murine mesoderm–derived tissues and mutated in a human mesothelioma
The tumour suppressor gene WT1 encodes a transcription factor expressed in tissues of the genito–urinary system. Inactivation of this gene is associated with the development of Wilms tumour a pediatric kidney ...
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Article
Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour
Nephrogenic rests consist of foci of primitive renal cells, typically microscopic, that are found within the normal kidney tissue of children with Wilms' tumour. To study the relationship between nephrogenic r...
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Article
The murine Xe169 gene escapes X–inactivation like its human homologue
Among a number of genes that escape X–chromosome inactivation in humans, three have been evaluated in mice and unexpectedly all three are subject to X–inactivation. We report here the cloning and expression st...
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Autosomal dominant hypocalcaemia caused by a Ca2+-sensing receptor gene mutation
Defects in the human Ca2+-sensing receptor gene have recently been shown to cause familial hypocalciuric hypercalcaemia and neonatal severe hyperparathyroidism. We now demonstrate that a missense mutation (Glu128...
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Article
Effect on splicing of a silent FGFR2 mutation in Crouzon syndrome
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Article
Failure of T-cell homeostasis preceding AIDS in HIV-1 infection
We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4+ or CD8+ phenotype (‘blind’ T-cell homeostasis). Here we confirm essentially constant T-cell leve...
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Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection
Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and tra...
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Breast cancer–associated antigen, DF3/MUC1, induces apoptosis of activated human T cells
Given the plethora of well–documented breast carcinoma–associated antigens in humans including MAGE–1, –2 and –3, mutated p53, p21ras, HER–2/neu and DF3/MUC–1, coupled with evidence that humoral and cytotoxic ...
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Article
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM), the most common cause of sudden death in the young, is an autosomal dominant disease characterized by ventricular hypertrophy accompanied by myofibrillar disarrays1. Linkage stu...
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Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for degradation of 5-fluorouracil (5-FU). DPD activity is highly variable in liver and peripheral mononuclear cells (PMNCs) and it has not been...
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Article
Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor-1 and -2
Transcriptional activator interferon regulatory factor (IRF)-1 and repressor IRF-2 are known to play a critical role in the regulation of interferon (IFN) responses and oncogenesis in fibroblasts. Although the...
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Article
Missense mutations in desmin associated with familial cardiac and skeletal myopathy
Desmin-related myopathy (OMIM 601419) is a familial disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias and restrictive heart failure, and by intracytoplas...
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Article
Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells
Although prostate cancer cells are often initially sensitive to androgen ablation, they eventually lose this response and continue to survive, grow and spread in the absence of androgenic steroid...
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Article
Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas
The gene defect for hereditary papillary renal carcinoma1 (HPRC) has recently been mapped to chromosome 7q, and germline mutations of MET (also known as c-met) at 7q31 have been detected in patients with HPRC (r...
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Article
Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts
Accelerated atherosclerosis in patients with diabetes is a major cause of their morbidity and mortality, and it is unresponsive to therapy aimed at restoring relative euglycemia. In hyperglycemia, nonenzymatic...
