-
Article
Open AccessMaternal and perinatal risks for monozygotic twins conceived following frozen-thawed embryo transfer: a retrospective cohort study
The present study aimed to explore the maternal and perinatal risks in cases of monozygotic twins (MZT) following frozen-thawed embryo transfer (FET).
-
Article
Chemotactic rhizocompetence is strengthened by efficient adaptational methylation modification of the 1-aminocyclopropane-1-carboxylic acid chemoreceptor in Pseudomonas sp. UW4
Intensifying chemotactic rhizocompetence is an effective approach to improving PGPR colonization in the plant rhizosphere and promoting plant growth. Whether increasing the efficient adaptational methylation m...
-
Article
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
-
Article
Open AccessMetabolomics analysis of follicular fluid in ovarian endometriosis women receiving progestin-primed ovary stimulation protocol for in vitro fertilization
This study aimed to investigate the metabolite profile and inflammatory state of follicular fluid (FF) in women with stage III–IV ovarian endometriosis (OE) who underwent in vitro fertilization (IVF). A cohort...
-
Article
Open AccessLive birth rate and neonatal outcomes following interventional embolization of hydrosalpinx
Hydrosalpinx has a negative effect on the pregnancy outcomes of in vitro fertilization and embryo transfer (IVF-ET), and the pretreatment for hydrosalpinx play an important role in improving the outcomes of IV...
-
Article
Open AccessA saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...
-
Article
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treat...
-
Article
Cross-sectional analysis of associated anomalies and vertebral anomaly location in 1289 surgical congenital scoliosis
This study systematically analyzed and assessed the interrelationships among vertebral anomaly location, congenital scoliosis (CS) type and associated abnormality prevalence.
-
Article
Open AccessOlder fusion-surgery age in congenital scoliosis patients is a risk factor for extended length of stay, more estimated blood loss, longer fused segments and higher medical costs: a retrospective study
Contradictory opinions about whether early correction and fusion surgeries should be performed for congenital scoliosis (CS) patients at a young age exist. The objectives of this study were to analyze the asso...
-
Article
Cross-sectional analysis and trend of vertebral and associated anomalies in Chinese congenital scoliosis population: a retrospective study of one thousand, two hundred and eighty nine surgical cases from 2010 to 2019
The objective of this article is to report associated anomaly incidences of a large CS cohort and analyze interrelationships among vertebral anomaly types and associated abnormalities.
-
Article
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregate...
-
Article
Open AccessThe effect of pedicle subtraction osteotomy for the correction of severe Scheuermann thoracolumbar kyphosis on sagittal spinopelvic alignment
To analyze how pedicle subtraction osteotomy (PSO) treatment of severe Scheuermann thoracolumbar kyphosis (STLK) using pedicle screw instrumentation affects sagittal spinopelvic parameters.
-
Chapter
Genetic Epidemiology of Quantitative Traits of Primary Open Angle Glaucoma
Nowadays, GWAS meta-analysis is the preferred approach for gene discovery in genetic studies to evaluate disease pathogenesis. This chapter comprehensively reviews the genetic epidemiology of primary open angl...
-
Article
Open AccessCommon variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract
Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h2 = 0.48), but little is known about specific genetic facto...
-
Article
The statistical practice of the GTEx Project: from single to multiple tissues
The Genotype-Tissue Expression (GTEx) Project has collected genetic and transcriptome profiles from a wide spectrum of tissues in nearly 1,000 ceased individuals, providing an opportunity to study the regulato...
-
Article
Open AccessThe role of combining medroxyprogesterone 17-acetate with human menopausal gonadotropin in mouse ovarian follicular development
Medroxyprogesterone 17-acetate (MPA) combined with human menopausal gonadotropin (hMG) has been effectively used for ovarian stimulation in clinical practice. However, the molecular mechanism of MPA + hMG trea...
-
Article
Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A
Calcium-activated chloride channels (CaCCs) play vital roles in a variety of physiological processes. Dysfunction of the CaCCs is implicated in many diseases. Drug discovery targeting at CaCCs has recently bec...
-
Article
Open AccessUse of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization
This study investigated the use of medroxyprogesterone acetate (MPA) or a short protocol for controlled ovarian hyperstimulation (COH) in patients with advanced endometriosis who have normal ovarian function, ...
-
Article
Open AccessControlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders
The use of progestin (P) during ovarian stimulation is effective in blocking the luteinizing hormone (LH) surge in women with normal ovarian reserve, however, its effects have not been determined in poor respo...
-
Article
Open AccessPolymorphism in the Alternative Donor Site of the Cryptic Exon of LHCGR: Functional Consequences and Associations with Testosterone Level
Selective splicing is a feature of luteinizing hormone receptor (LHCGR). A cryptic exon (LHCGR-exon 6A) was found to be derived from alternative splicing in intron 6 of the LHCGR gene, which including two transcr...
